UCHL1 and CDKN1B

Number of citations of the paper that reports this interaction (PubMedID 12082530)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		UCHL1	CDKN1B
Description		ubiquitin C-terminal hydrolase L1	cyclin dependent kinase inhibitor 1B
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm	Nucleus Nucleoplasm Cytoplasm Endosome Centrosome Cytosol Cilium Cul4A-RING E3 Ubiquitin Ligase Complex Ciliary Basal Body
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Omega Peptidase Activity Hydrolase Activity Signaling Receptor Inhibitor Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ribosome Binding Ubiquitin Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Cyclin-dependent Protein Kinase Regulator Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein-folding Chaperone Binding Molecular Adaptor Activity Molecular Function Inhibitor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Male Germ Cell Proliferation Response To Ischemia Proteolysis Ubiquitin-dependent Protein Catabolic Process Axonogenesis Axon Target Recognition Adult Walking Behavior Regulation Of Macroautophagy Protein Deubiquitination Axonal Transport Of Mitochondrion Protein Catabolic Process Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Glycolytic Process Neuromuscular Process Muscle Cell Development Cellular Response To Xenobiotic Stimulus	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Placenta Development Potassium Ion Transport Apoptotic Process Regulation Of Exit From Mitosis Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Heart Development Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Programmed Cell Death Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Negative Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Negative Regulation Of DNA-templated Transcription Negative Regulation Of Growth Negative Regulation Of Mitotic Cell Cycle Autophagic Cell Death Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Nuclear Export Regulation Of Cell Cycle Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cellular Response To Lithium Ion Cellular Senescence Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Lens Fiber Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition Epithelial Cell Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		UCH proteinases	SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RHO GTPases activate CIT Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle FLT3 Signaling FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs		Phenethyl Isothiocyanate
Diseases		Parkinson's disease (PD)	Prostate cancer
GWAS		Cognitive performance ( 19734545) Metabolite levels ( 23823483)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Mean arterial pressure ( 29403010 30487518) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Plateletcrit ( 32888494) Prostate cancer ( 29892016 31562322) Refractive error ( 32231278) Systemic lupus erythematosus ( 23273568 33272962) Systolic blood pressure ( 30487518) Type 2 diabetes ( 30297969)
Interacting Genes		30 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 RNF4 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBB UBC UBE2I USP15 USP21 USP28	70 interacting genes: ABL1 AKT1 ARHGDIA ARIH1 CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE2 CDC34 CDK2 CDK3 CDK4 CDK5 CKS1B COP1 COPS5 CUL4A DCLRE1C GRB2 H1-1 H1-5 IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 MTUS2 MYC NUP50 PIN1 PSMB1 RCHY1 RNF123 RNF6 RPS6KA1 SGK1 SIRT6 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE2L3 UBE3A UCHL1 WWP1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		7345	1027
HPRD ID		01877	02867
Ensembl ID		ENSG00000154277	ENSG00000111276
Uniprot IDs		P09936 V9HW74	P46527 Q6I9V6
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ 7ZM0 8DY8 8EDE 8PW1 8XI7	1H27 1JSU 2AST 5UQ3 6ATH 6P8E 6P8F 6P8G 7B5L 7B5M 7B5R 7OR8 7ORG 7ORH 7ORS 7ORT 8BYA 8BYL 8BZO
Enriched GO Terms of Interacting Partners?		Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Post-translational Protein Modification Nuclear Body Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Chaperone-mediated Autophagy Regulation Of Muscle System Process Enzyme Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Positive Regulation Of Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Intracellular Signal Transduction Protein Tag Activity Macromolecule Metabolic Process Nucleoplasm Regulation Of Smooth Muscle Contraction Regulation Of System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Modification Process ERBB Signaling Pathway Regulation Of Signal Transduction Regulation Of Muscle Contraction Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Norepinephrine Binding Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Proteolysis Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Catecholamine Secretion DeNEDDylase Activity Shelterin Complex Macromolecule Catabolic Process Protein Modification By Small Protein Removal Regulation Of Signaling Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Protein Ubiquitination Response To Stress Nitric-oxide Synthase Regulator Activity	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Modification Process Nucleus Cell Cycle Phase Transition Nucleoplasm Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cytosol Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Metabolic Process Macromolecule Catabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Cell Cycle Proteolysis Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Catabolic Process Protein Polyubiquitination Protein Localization To Nucleus Transferase Activity NLS-dependent Protein Nuclear Import Complex Regulation Of Macromolecule Metabolic Process Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity NLS-bearing Protein Import Into Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of DNA Metabolic Process Protein Import Into Nucleus Import Into Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Protein Kinase Binding Phosphoserine Residue Binding
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