TRIO and ITSN2

Number of citations of the paper that reports this interaction (PMID 22558309)
5

Data Source:
BioGRID (two hybrid)

		TRIO	ITSN2
Gene Name		trio Rho guanine nucleotide exchange factor	intersectin 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Enzyme Binding	SH3/SH2 Adaptor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Endocytosis Positive Regulation Of Signal Transduction Positive Regulation Of Rho GTPase Activity
Pathways		G alpha (q) signalling events Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE DCC mediated attractive signaling p75 NTR receptor-mediated signalling Rho GTPase cycle G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Netrin-1 signaling
Drugs
Diseases
GWAS		Paclitaxel-induced neuropathy ( 23776197)	Working memory ( 21107309)
Protein-Protein Interactions		11 interactors: BLMH CDC5L DISC1 EXOC1 FLNA ITSN2 MAPRE1 PTK2 PTPRF RAC1 RHOA	75 interactors: AGT AHDC1 AMPH ANKRD17 BCCIP CBL CCDC88C CHIC2 CPSF6 DLGAP1 DNM2 DST EPS15 EPS15L1 ERC1 FASLG FCHSD1 FCHSD2 FNBP4 GAREML GOLGA2 GOLGA8A GOLGB1 GPNMB HNRNPK HOOK2 ITPKA ITSN1 KCTD10 KDM1A KHDRBS1 KIAA1549 KXD1 LARP6 LSM8 LTBP4 LUC7L3 MAP4K3 MBNL1 MEGF10 NBR1 NR2C2 PDCD6IP PDE4DIP PIK3AP1 PIK3C2B PSEN1 PTN RABEP1 RAD9A RBMX REPS1 RNF20 ROCK1 RUFY1 SEMA6A SH3GL1 SH3KBP1 SNAP29 SOS1 SOS2 STX4 SYN1 SYNJ2 TACC1 TBL3 TMF1 TRIO WAS WASF2 WASL WIPF1 WIPF2 YLPM1 YTHDF1
Entrez ID		7204	50618
HPRD ID		03537	09193
Ensembl ID		ENSG00000038382	ENSG00000198399
Uniprot IDs		O75962	A6H8W8 Q9NZM3
PDB IDs		1NTY 2NZ8	1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Signal Transduction Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Migration Cell Motility Blood Coagulation Hemostasis Microtubule Cytoskeleton Organization Mitotic Spindle Assembly Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cytoskeleton Organization Regulation Of Body Fluid Levels Wound Healing Locomotion Organelle Organization Positive Regulation Of Transcription Factor Import Into Nucleus Mitotic Spindle Organization Cell Activation Positive Regulation Of Stress Fiber Assembly Response To Wounding Regulation Of Focal Adhesion Assembly Cell Morphogenesis Involved In Differentiation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Vesicle-mediated Transport Negative Regulation Of Axonogenesis Microtubule-based Process Cellular Localization Movement Of Cell Or Subcellular Component Regulation Of Lipid Kinase Activity Regulation Of Cell Junction Assembly Mitotic Nuclear Division Positive Regulation Of Intracellular Signal Transduction Cerebral Cortex Radially Oriented Cell Migration Regulation Of Stress Fiber Assembly Cell Projection Morphogenesis Regulation Of Rho Protein Signal Transduction Regulation Of Cell Development Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Projection Development Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity	Vesicle-mediated Transport Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Cell Communication Signaling Cellular Response To Stimulus Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Component Assembly Signal Transduction Synaptic Vesicle Transport Enzyme Linked Receptor Protein Signaling Pathway Actin Filament-based Movement Cell-cell Signaling Response To Stimulus Establishment Of Vesicle Localization Cell Surface Receptor Signaling Pathway Vesicle Localization Organelle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Negative Regulation Of Membrane Tubulation Regulation Of Signaling Protein Complex Assembly Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Vesicle Organization Establishment Of Organelle Localization Positive Regulation Of Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Immune Response-regulating Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Cell Death Transport Apoptotic Process Cellular Localization Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Vesicle-mediated Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Establishment Of Localization In Cell Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway
Tagcloud ?		accelerating accidents attends battlefield blades boat collisions devastating falls histories imparted inflicted observer obstacles operator propeller recreational rope shearing skier sport sporting sports tow trauma unobstructed vigorous waterskiing wounds	abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates
Tagcloud (Difference) ?		accelerating accidents attends battlefield blades boat collisions devastating falls histories imparted inflicted observer obstacles operator propeller recreational rope shearing skier sport sporting sports tow trauma unobstructed vigorous waterskiing wounds	abl1 adaptor clathrin colocalize crk domains enabled endocytosis fgr fyn hela interactors interface intersectin isoform isoforms itsn1 itsns mentioned paralogous pathologies phospholipase scaffolding sh2 sh3 tyrosines unable vertebrates
Tagcloud (Intersection) ?