TRIO and BLMH

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		TRIO	BLMH
Name		trio Rho guanine nucleotide exchange factor	bleomycin hydrolase
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extrinsic Component Of Membrane Cell Projection Presynaptic Active Zone Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Aminopeptidase Activity Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Cysteine-type Aminopeptidase Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Axon Guidance Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Postsynaptic Modulation Of Chemical Synaptic Transmission	Protein Polyubiquitination Proteolysis Response To Xenobiotic Stimulus Response To Toxic Substance Homocysteine Catabolic Process
Pathways		NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145 ) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811 ) Asthma ( 31959851 ) Asthma (childhood onset) ( 31036433 ) Electroencephalogram traits ( 25387704 ) High density lipoprotein cholesterol levels ( 30498476 ) Intake of total sugars ( 31005972 ) Major depressive disorder ( 27777418 ) Paclitaxel-induced neuropathy ( 23776197 ) Physiological dysregulation (Mahalanobis distance) ( 32235003 ) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417 ) Waist circumference ( 28552196 )	No GWAS studies recorded
Interacting Genes		13 interacting genes: BLMH CDC42 CDC5L DISC1 DSCR9 EXOC1 FLNA ITSN2 LIMS1 PTK2 PTPRF RAC1 RHOA	20 interacting genes: AP1M2 APP CDC42 CEBPA CYP2C8 ECSIT KBTBD7 MAST1 NTAQ1 NXF1 PDPK1 PGLS RNF32 RPL11 RPL29 TNPO2 TNPO3 TRIM47 TRIO UBE2I
Entrez ID		7204	642
HPRD ID		03537	03870
Ensembl ID		ENSG00000038382	ENSG00000108578
Uniprot IDs		O75962	Q13867
PDB IDs		1NTY 2NZ8 6D8Z 7SJ4	1CB5 2CB5 7V5L 7V5S 7V5T 7XF9
GO Terms Enriched among Interactors		Regulation Of Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Junction Organization Focal Adhesion Cerebral Cortex Cell Migration Cell Motility Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Forebrain Cell Migration Membrane Invagination Positive Regulation Of Cell Migration Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Migration Positive Regulation Of Stress Fiber Assembly Cell Migration Positive Regulation Of Cell Motility Establishment Or Maintenance Of Cell Polarity Non-canonical Wnt Signaling Pathway G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Locomotion Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Supramolecular Fiber Organization Cell Projection Assembly Cell-cell Junction Organization Cell Cortex Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Cytoskeleton Organization Thioesterase Binding G Protein Activity Cell Projection Organization Protein Kinase Binding Positive Regulation Of Integrin-mediated Signaling Pathway Postsynapse Positive Regulation Of Neuron Migration Establishment Of Cell Polarity Positive Regulation Of Growth Regulation Of Neural Precursor Cell Proliferation Regulation Of Stress Fiber Assembly Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Actin Filament Organization Establishment Of Epithelial Cell Apical/basal Polarity	Cytosol Cytoplasm Postsynapse Intracellular Transport Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity