TRIO and BLMH

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIO	BLMH
Gene Name		trio Rho guanine nucleotide exchange factor	bleomycin hydrolase
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Enzyme Binding	Aminopeptidase Activity Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Protein Polyubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Proteolysis Response To Toxic Substance Response To Drug
Pathways		G alpha (q) signalling events Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE DCC mediated attractive signaling p75 NTR receptor-mediated signalling Rho GTPase cycle G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Netrin-1 signaling	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Paclitaxel-induced neuropathy ( 23776197)
Protein-Protein Interactions		11 interactors: BLMH CDC5L DISC1 EXOC1 FLNA ITSN2 MAPRE1 PTK2 PTPRF RAC1 RHOA	14 interactors: AP1M2 APP CYP2C8 ECSIT KBTBD7 MAST1 NUDT12 PDPK1 RNF32 RPL11 RPL29 TRIO UBE2I WDYHV1
Entrez ID		7204	642
HPRD ID		03537	03870
Ensembl ID		ENSG00000038382	ENSG00000108578
Uniprot IDs		O75962	E7EMN3 Q13867
PDB IDs		1NTY 2NZ8	1CB5 2CB5
Enriched GO Terms of Interacting Partners?		Platelet Activation Positive Regulation Of Signal Transduction Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Migration Cell Motility Blood Coagulation Hemostasis Microtubule Cytoskeleton Organization Mitotic Spindle Assembly Regulation Of Cell Projection Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Phosphatidylinositol 3-kinase Activity Cytoskeleton Organization Regulation Of Body Fluid Levels Wound Healing Locomotion Organelle Organization Positive Regulation Of Transcription Factor Import Into Nucleus Mitotic Spindle Organization Cell Activation Positive Regulation Of Stress Fiber Assembly Response To Wounding Regulation Of Focal Adhesion Assembly Cell Morphogenesis Involved In Differentiation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Vesicle-mediated Transport Negative Regulation Of Axonogenesis Microtubule-based Process Cellular Localization Movement Of Cell Or Subcellular Component Regulation Of Lipid Kinase Activity Regulation Of Cell Junction Assembly Mitotic Nuclear Division Positive Regulation Of Intracellular Signal Transduction Cerebral Cortex Radially Oriented Cell Migration Regulation Of Stress Fiber Assembly Cell Projection Morphogenesis Regulation Of Rho Protein Signal Transduction Regulation Of Cell Development Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Projection Development Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity	Viral Process NAD Catabolic Process Positive Regulation Of SUMO Transferase Activity Cellular Protein Metabolic Process Viral Transcription Axon Guidance Synaptic Growth At Neuromuscular Junction Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Protein Targeting Establishment Of Protein Localization To Endoplasmic Reticulum NADP Catabolic Process Collateral Sprouting In Absence Of Injury Aromatic Compound Catabolic Process Catabolic Process Regulation Of Receptor Activity Protein Localization To Endoplasmic Reticulum Axonogenesis Collateral Sprouting Axon Midline Choice Point Recognition Translational Termination MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Establishment Of Localization In Cell Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Development Protein Metabolic Process MRNA Catabolic Process Protein Targeting To Membrane Cell Morphogenesis Involved In Neuron Differentiation Locomotion Axon Choice Point Recognition Chemotaxis Translational Elongation Cellular Protein Modification Process RNA Catabolic Process Protein Phosphorylation Neuron Projection Morphogenesis Cellular Protein Complex Disassembly Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Omega-hydroxylase P450 Pathway Viral Life Cycle Cellular Protein Localization Platelet Activation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Neuron Remodeling Protein Complex Disassembly
Tagcloud ?		accelerating accidents attends battlefield blades boat collisions devastating falls histories imparted inflicted observer obstacles operator propeller recreational rope shearing skier sport sporting sports tow trauma unobstructed vigorous waterskiing wounds	17q11 accn1 addressing amiloride bleomycin breakpoint breakpoints centromeric contig correctly deletions disabilities dysmorphism extending gross hydrolase mb mosaicism neurofibromatosis nf1 premise retardation smallest sro supt6h tagged telomerically yac yacs
Tagcloud (Difference) ?		accelerating accidents attends battlefield blades boat collisions devastating falls histories imparted inflicted observer obstacles operator propeller recreational rope shearing skier sport sporting sports tow trauma unobstructed vigorous waterskiing wounds	17q11 accn1 addressing amiloride bleomycin breakpoint breakpoints centromeric contig correctly deletions disabilities dysmorphism extending gross hydrolase mb mosaicism neurofibromatosis nf1 premise retardation smallest sro supt6h tagged telomerically yac yacs
Tagcloud (Intersection) ?