TRIO and DNAH5

Data Source: HiPPIP (Novel)

		TRIO	DNAH5
Name		trio Rho guanine nucleotide exchange factor	dynein axonemal heavy chain 5
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extrinsic Component Of Membrane Cell Projection Presynaptic Active Zone Postsynapse Glutamatergic Synapse	Extracellular Region Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Outer Dynein Arm Cell Projection Glial Cell Projection 9+0 Motile Cilium 9+2 Motile Cilium
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Axon Guidance Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction Postsynaptic Modulation Of Chemical Synaptic Transmission	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Microtubule-based Movement Determination Of Left/right Symmetry Heart Development Lateral Ventricle Development Flagellated Sperm Motility Outer Dynein Arm Assembly Establishment Of Localization In Cell Cilium Assembly Cilium Movement Involved In Cell Motility
Pathways		NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	None
Diseases		None	Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145 ) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811 ) Asthma ( 31959851 ) Asthma (childhood onset) ( 31036433 ) Electroencephalogram traits ( 25387704 ) High density lipoprotein cholesterol levels ( 30498476 ) Intake of total sugars ( 31005972 ) Major depressive disorder ( 27777418 ) Paclitaxel-induced neuropathy ( 23776197 ) Physiological dysregulation (Mahalanobis distance) ( 32235003 ) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417 ) Waist circumference ( 28552196 )	Antidepressant treatment resistance (number of drugs prescribed) ( 30700811 ) Coffee consumption ( 29367735 ) Cognitive function in longevity ( 33607172 ) Corneal astigmatism ( 23322567 ) Emphysema imaging phenotypes ( 26030696 ) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821 ) IgE grass sensitization ( 22036096 ) Post bronchodilator FEV1 in COPD ( 26634245 ) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 ) Subclinical atherosclerosis traits (other) ( 17903303 ) Thyroid volume in Hashimoto’s thyroiditis ( 32019955 ) Toxicity response to radiotherapy in prostate cancer (decreased urine stream) (time to event) ( 27515689 ) Visceral fat ( 22589738 )
Interacting Genes		13 interacting genes: BLMH CDC42 CDC5L DISC1 DSCR9 EXOC1 FLNA ITSN2 LIMS1 PTK2 PTPRF RAC1 RHOA	2 interacting genes: MTDH USP7
Entrez ID		7204	1767
HPRD ID		03537	04514
Ensembl ID		ENSG00000038382	ENSG00000039139
Uniprot IDs		O75962	Q8TE73
PDB IDs		1NTY 2NZ8 6D8Z 7SJ4	8J07
GO Terms Enriched among Interactors		Regulation Of Cell-substrate Adhesion Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Focal Adhesion Assembly Regulation Of Cell-substrate Junction Organization Focal Adhesion Cerebral Cortex Cell Migration Cell Motility Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Telencephalon Cell Migration Semaphorin-plexin Signaling Pathway Forebrain Cell Migration Membrane Invagination Positive Regulation Of Cell Migration Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Migration Positive Regulation Of Stress Fiber Assembly Cell Migration Positive Regulation Of Cell Motility Establishment Or Maintenance Of Cell Polarity Non-canonical Wnt Signaling Pathway G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Locomotion Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Supramolecular Fiber Organization Cell Projection Assembly Cell-cell Junction Organization Cell Cortex Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Cytoskeleton Organization Thioesterase Binding G Protein Activity Cell Projection Organization Protein Kinase Binding Positive Regulation Of Integrin-mediated Signaling Pathway Postsynapse Positive Regulation Of Neuron Migration Establishment Of Cell Polarity Positive Regulation Of Growth Regulation Of Neural Precursor Cell Proliferation Regulation Of Stress Fiber Assembly Regulation Of Cell Junction Assembly Actin Filament Organization Regulation Of Actin Filament Organization Establishment Of Epithelial Cell Apical/basal Polarity	Signal Transduction