TOP2A and COPS5

Number of citations of the paper that reports this interaction (PMID 15126503)
8

Data Source:
BioGRID (pull down)

		TOP2A	COPS5
Gene Name		topoisomerase (DNA) II alpha 170kDa	COP9 signalosome subunit 5
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Nucleus Nucleoplasm Nucleolus Centriole Nucleoid DNA Topoisomerase Complex (ATP-hydrolyzing) Viral Integration Complex Protein Complex	Nucleus Nucleoplasm Cytoplasm Eukaryotic Translation Initiation Factor 3 Complex Synaptic Vesicle COP9 Signalosome Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Drug Binding DNA Binding, Bending Enzyme Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Transcription Coactivator Activity Translation Initiation Factor Activity Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Topological Change DNA Ligation DNA Unwinding Involved In DNA Replication Mitotic Recombination Cellular Response To DNA Damage Stimulus Chromosome Segregation Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Mitotic DNA Integrity Checkpoint Positive Regulation Of Viral Genome Replication Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription From RNA Polymerase II Promoter	Protein Deneddylation Transcription From RNA Polymerase II Promoter Translation Translational Initiation Proteolysis Cullin Deneddylation Protein Deubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of JNK Cascade Regulation Of Cell Cycle Exosomal Secretion
Pathways		G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Lomefloxacin Doxorubicin Norfloxacin Levofloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone
Diseases
GWAS
Protein-Protein Interactions		22 interactors: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 HDAC1 HDAC2 JUN MAPK1 PIN1 PRKCA PRKCB PRKCG RB1 SRPK1 SUMO1 SUMO4 TOP2B TP53 XPO1 YWHAE	90 interactors: APCS ARFGAP1 ATRN BCL2L14 BCL3 C12orf10 C6orf203 CACNA1C CD93 CDKN1B CENPT CHUK COPS2 COPS3 COPS4 COPS6 COPS7A COPS8 CUL1 CUL2 CUL4A CUL5 DDB1 DDO ERN1 ESR1 F2RL1 GFER GFI1B GPS1 HAND2 HIF1A HNF4A HNF4G HTR6 HUS1 ITGB2 JUN JUND LOC284014 MAP2K2 MAP3K11 MAP3K3 MAP3K7 MAP4K3 MAP4K5 MAPK14 MAPRE1 MAX MDC1 MDM2 MEF2C MEF2D MIF NCOA1 NEDD8 NFKB1 NR4A2 NR4A3 NR5A2 OPRM1 PGR PLAC8 PPARG PPOX PPP1CC PRDX2 PRKD1 PTGS2 RAD1 RAD9A RNF139 RORA S100A7 SHANK3 SHISA5 SMAD2 SMAD4 SMAD5 SPP1 SREBF2 TOP2A TP53 TXN TYK2 UCHL1 USP14 VTN WNK1 YWHAG
Entrez ID		7153	10987
HPRD ID		00536	06888
Ensembl ID		ENSG00000131747	ENSG00000121022
Uniprot IDs		P11388	Q92905
PDB IDs		1LWZ 1ZXM 1ZXN 4FM9	4F7O
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Cell Cycle Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Response To Growth Factor Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Apoptotic Process Regulation Of Signaling Programmed Cell Death Chromosome Organization Mitotic Cell Cycle Regulation Of Protein Metabolic Process Cell Death Death Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Organelle Organization Response To Wounding Rhythmic Process Response To Stress Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Cell Cycle Checkpoint Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Signal Transduction Cellular Protein Modification Process Blood Coagulation Nucleobase-containing Compound Metabolic Process Immune Response Nucleus Organization Hemostasis Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mitotic Cell Cycle Process Negative Regulation Of Cell Death Peptidyl-threonine Phosphorylation Developmental Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Positive Regulation Of Cellular Metabolic Process Response To Stress Cellular Response To Stimulus Response To Stimulus Cellular Response To Stress Positive Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Organic Substance Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Gene Expression Signaling Cullin Deneddylation Positive Regulation Of Cellular Biosynthetic Process Death Anatomical Structure Development Cellular Response To Organic Substance Response To Abiotic Stimulus Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Cellular Process Response To Lipid Developmental Process Cell Death Multicellular Organismal Development Protein Deneddylation Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Response To Organic Cyclic Compound Apoptotic Process Programmed Cell Death System Development Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To Radiation Organ Development Defense Response Cell Proliferation Regulation Of Phosphorus Metabolic Process
Tagcloud ?		adjacent adr adriamycin allelic antineoplastic chimeric chromatin close decondensed description disruption fibers fish fluorescence fusion hybridization juxtaposition metaphase murine proximity rara rearrangement resistant separate situ topoisomerase transcript truncated	abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite
Tagcloud (Difference) ?		adjacent adr adriamycin allelic antineoplastic chimeric chromatin close decondensed description disruption fibers fish fluorescence fusion hybridization juxtaposition metaphase murine proximity rara rearrangement resistant separate situ topoisomerase transcript truncated	abeta apdeltae9 app bace1 brains coimmunoprecipitation colocalization compartments consequently exists forming generation implying interacting library lipoprotein multiprotein neurotoxic plaque ranbp9 robustly sapp scaffold sirnas soluble stabilizing subcellular supported tripartite
Tagcloud (Intersection) ?