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TOP2A and XPO1
Number of citations of the paper that reports this interaction (PubMedID
12821127
)
0
Data Source:
HPRD
(in vivo, in vitro)
TOP2A
XPO1
Description
DNA topoisomerase II alpha
exportin 1
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Centromeric Region
Condensed Chromosome
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centriole
DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex
Protein-containing Complex
Ribonucleoprotein Complex
Kinetochore
Nucleus
Nuclear Envelope
Annulate Lamellae
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cajal Body
Membrane
Nuclear Membrane
Protein-containing Complex
Ribonucleoprotein Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
DNA Binding
Chromatin Binding
RNA Binding
DNA Topoisomerase Activity
DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
DNA Binding, Bending
Isomerase Activity
Protein Homodimerization Activity
Ubiquitin Binding
Metal Ion Binding
Protein Heterodimerization Activity
RNA Binding
Nuclear Export Signal Receptor Activity
Protein Binding
Protein Domain Specific Binding
Small GTPase Binding
DNA-binding Transcription Factor Binding
Biological Process
Resolution Of Meiotic Recombination Intermediates
Sister Chromatid Segregation
Hematopoietic Progenitor Cell Differentiation
DNA Metabolic Process
DNA Topological Change
Chromatin Organization
DNA Damage Response
Chromosome Segregation
Female Meiotic Nuclear Division
Chromosome Condensation
Apoptotic Chromosome Condensation
Embryonic Cleavage
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Ribosomal Subunit Export From Nucleus
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
MRNA Export From Nucleus
Protein Export From Nucleus
Intracellular Protein Transport
Nucleocytoplasmic Transport
Response To Xenobiotic Stimulus
Regulation Of Centrosome Duplication
Protein Transport
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Regulation Of Protein Catabolic Process
Ribosome Biogenesis
Regulation Of Protein Export From Nucleus
MRNA Transport
Cellular Response To Triglyceride
Cellular Response To Salt
Pathways
Transcription of E2F targets under negative control by DREAM complex
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Rev-mediated nuclear export of HIV RNA
NEP/NS2 Interacts with the Cellular Export Machinery
Downregulation of TGF-beta receptor signaling
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Deactivation of the beta-catenin transactivating complex
HuR (ELAVL1) binds and stabilizes mRNA
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Mitotic Prometaphase
Cyclin A/B1/B2 associated events during G2/M transition
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
EML4 and NUDC in mitotic spindle formation
Heme signaling
NPAS4 regulates expression of target genes
Maturation of hRSV A proteins
Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Moxifloxacin
Amsacrine
Dexrazoxane
Valrubicin
Teniposide
Epirubicin
Enoxacin
Pefloxacin
Ciprofloxacin
Trovafloxacin
Daunorubicin
Etoposide
Dactinomycin
Lomefloxacin
Doxorubicin
Norfloxacin
Norfloxacin
Ofloxacin
Idarubicin
Podofilox
Mitoxantrone
Sparfloxacin
Genistein
Fleroxacin
Lucanthone
Banoxantrone
SP1049C
Amonafide
Elsamitrucin
13-deoxydoxorubicin
RTA 744
Aldoxorubicin
ZEN-012
Amrubicin
Becatecarin
Annamycin
Declopramide
Finafloxacin
Selinexor
Diseases
GWAS
Appendicular lean mass (
33097823
)
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
25673412
)
Neutrophil percentage of white cells (
32888494
)
Atrial fibrillation (
29892015
)
Eosinophil count (
27863252
32888494
)
Erectile dysfunction (
30583798
)
Mean reticulocyte volume (
32888494
)
Monocyte count (
32888494
)
Neutrophil count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systemic lupus erythematosus (
28714469
)
Urinary sodium excretion (
31409800
)
White blood cell count (
32888494
)
Interacting Genes
36 interacting genes:
ATM
BRCA1
CDK1
CEBPA
COPS5
CSNK2A1
DFFB
DHX9
FBXO28
GINS1
HDAC1
HDAC2
HNRNPD
JUN
MAPK1
MDM4
PIAS4
PIN1
PLK1
PRKCA
PRKCB
PRKCG
RB1
RNF10
RNF168
SMURF2
SRPK1
SUMO1
SUMO2
SUMO4
TOP2B
TP53
UBE2I
USP7
XPO1
YWHAE
86 interacting genes:
ABL1
ADAR
AGFG1
AHR
ANP32A
ANP32B
APC
ATF2
BECN1
BIRC5
BRCA2
CCND1
CDC25A
CDC42
CDCA4
CDK1
CDKN1B
CEBPA
CHEK1
CHORDC1
CIITA
CRK
DDX3X
DESI1
DR1
E2F4
E2F5
EIF4E
EIF5A
ERF
FBXO7
FILNC1
FOXO4
HDAC3
HNF4A
HSPA9
HSPB1
IRF5
KIF17
LINC01554
LRPPRC
MAPK6
NF2
NMD3
NOSIP
NPM1
NUCB1
NUCB2
NUP153
NUP214
NUP50
NUP62
NXF3
NXT1
OGT
ORC1
PHAX
PHB1
PKIA
RAD51
RAN
RANBP2
RANBP3
RCC1
RCN2
RGS14
RIC8A
RPS6KB1
SERPINB1
SERTAD2
SIRT2
SMAD1
SMARCB1
SMURF1
SMURF2
SNUPN
SOX2
STAT1
STRADA
SUMO2
TERF2IP
TERT
TOP2A
TOP2B
TP53
TP73
Entrez ID
7153
7514
HPRD ID
00536
03975
Ensembl ID
ENSG00000131747
ENSG00000082898
Uniprot IDs
P11388
A0A7I2V2Y6
A0A7I2V461
A0A7I2V6B9
B3KWD0
O14980
PDB IDs
1ZXM
1ZXN
4FM9
4R1F
5GWK
5NNE
6ZY5
6ZY6
6ZY7
6ZY8
8W50
1W9C
2L1L
3GB8
4BSM
4BSN
5DIS
6TVO
7B51
9B62
Enriched GO Terms of Interacting Partners
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Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Protein Modification Process
Regulation Of RNA Biosynthetic Process
Nucleoplasm
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of DNA Metabolic Process
Nucleus
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Regulation Of Macromolecule Biosynthetic Process
Enzyme Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Protein Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Intracellular Signal Transduction
Cellular Response To Stress
Negative Regulation Of RNA Metabolic Process
PML Body
Regulation Of Cell Cycle
DNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Regulation Of Cellular Response To Stress
Signal Transduction In Response To DNA Damage
Regulation Of DNA Repair
DNA Damage Checkpoint Signaling
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Response To Stress
Rhythmic Process
Presynaptic Cytosol
Regulation Of Protein Catabolic Process
Postsynaptic Cytosol
Regulation Of Proteolysis
Mitotic Nuclear Membrane Disassembly
Chromatin Organization
Regulation Of Proteasomal Protein Catabolic Process
Nuclear Transport
Nucleocytoplasmic Transport
Nuclear Export
Nucleoplasm
Nucleus
Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Cytoplasm
Intracellular Transport
Protein Export From Nucleus
Regulation Of Primary Metabolic Process
RNA Transport
Establishment Of Localization In Cell
Protein Import Into Nucleus
Import Into Nucleus
Cellular Localization
Intracellular Protein Transport
Protein-containing Complex
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cell Cycle
Nuclear Pore
Establishment Of Protein Localization To Organelle
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of RNA Biosynthetic Process
Nucleobase-containing Compound Transport
Positive Regulation Of Mitotic Cell Cycle
Intracellular Signal Transduction
Protein Localization To Nucleus
Cytosol
Positive Regulation Of Metabolic Process
RNA Export From Nucleus
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Cell Cycle
Positive Regulation Of RNA Metabolic Process
Chromatin Binding
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Protein Localization To Organelle
Negative Regulation Of Mitotic Cell Cycle
DNA Binding
MRNA Transport
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Positive Regulation Of DNA-templated Transcription
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