TOP2A and GINS1

Number of citations of the paper that reports this interaction (PubMedID 36065190)
46

Data Source:
BioGRID (pull down, pull down)

		TOP2A	GINS1
Description		DNA topoisomerase II alpha	GINS complex subunit 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Male Germ Cell Nucleus Nucleus Nucleoplasm Nucleolus Cytoplasm Centriole DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Protein-containing Complex Ribonucleoprotein Complex	GINS Complex Nucleus Nucleoplasm Chromosome Cytoplasm CMG Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding DNA Binding Chromatin Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA DNA Binding, Bending Isomerase Activity Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Metabolic Process DNA Topological Change Chromatin Organization DNA Damage Response Chromosome Segregation Female Meiotic Nuclear Division Chromosome Condensation Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	Inner Cell Mass Cell Proliferation DNA Replication DNA Strand Elongation Involved In Mitotic DNA Replication
Pathways		Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins	Unwinding of DNA Unwinding of DNA
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Norfloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin 13-deoxydoxorubicin RTA 744 Aldoxorubicin ZEN-012 Amrubicin Becatecarin Annamycin Declopramide Finafloxacin
Diseases
GWAS		Appendicular lean mass ( 33097823) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Neutrophil percentage of white cells ( 32888494)	Brain morphology (MOSTest) ( 32665545) Liver enzyme levels (alkaline phosphatase) ( 22001757) Platelet count ( 32888494) Telomere length ( 30185882)
Interacting Genes		36 interacting genes: ATM BRCA1 CDK1 CEBPA COPS5 CSNK2A1 DFFB DHX9 FBXO28 GINS1 HDAC1 HDAC2 HNRNPD JUN MAPK1 MDM4 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF10 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I USP7 XPO1 YWHAE	2 interacting genes: TOP2A TOPBP1
Entrez ID		7153	9837
HPRD ID		00536	11067
Ensembl ID		ENSG00000131747	ENSG00000101003
Uniprot IDs		P11388	A0A8Q3WLJ3 A0A8Q3WLK7 A0A8Q3WLL7 Q14691
PDB IDs		1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE 6ZY5 6ZY6 6ZY7 6ZY8 8W50	2E9X 2EHO 2Q9Q 6XTX 6XTY 7PFO 7PLO 8B9D 8OK2
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Modification Process Regulation Of RNA Biosynthetic Process Nucleoplasm Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of RNA Metabolic Process PML Body Regulation Of Cell Cycle DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Signal Transduction In Response To DNA Damage Regulation Of DNA Repair DNA Damage Checkpoint Signaling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Rhythmic Process Presynaptic Cytosol Regulation Of Protein Catabolic Process Postsynaptic Cytosol Regulation Of Proteolysis Mitotic Nuclear Membrane Disassembly Chromatin Organization Regulation Of Proteasomal Protein Catabolic Process	Male Germ Cell Nucleus Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Broken Chromosome Clustering DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Chromosome Organization BRCA1-B Complex Apoptotic Chromosome Condensation DNA Topoisomerase Activity DNA Topological Change Embryonic Cleavage Double-strand Break Repair Via Alternative Nonhomologous End Joining Phosphorylation-dependent Protein Binding Mitotic DNA Replication Checkpoint Signaling Double-strand Break Repair Via Classical Nonhomologous End Joining Resolution Of Meiotic Recombination Intermediates DNA Metabolic Process Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate DNA Damage Response DNA Binding, Bending DNA Conformation Change Female Meiotic Nuclear Division DNA Replication Checkpoint Signaling Chromatin-protein Adaptor Activity Chromatin Organization Protein Localization To Site Of Double-strand Break DNA Replication Initiation Nuclear Chromosome ATP-dependent Activity, Acting On DNA Positive Regulation Of Viral Genome Replication Condensed Chromosome Mitotic G2 DNA Damage Checkpoint Signaling Chromosome Condensation Homologous Recombination Sister Chromatid Segregation Site Of DNA Damage Protein Kinase C Binding Condensed Nuclear Chromosome Nuclear Chromosome Segregation Mitotic G2/M Transition Checkpoint Double-strand Break Repair Via Nonhomologous End Joining Meiosis I Cell Cycle Process Cellular Response To Stress Positive Regulation Of Viral Process Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Damage Checkpoint Signaling Protein Serine/threonine Kinase Activator Activity Meiotic Nuclear Division
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