TOP2A and HDAC2

  • Number of citations of the paper that reports this interaction (PMID 11062478)
  • 32
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vivo)

TOP2A

HDAC2

Gene Name topoisomerase (DNA) II alpha 170kDa histone deacetylase 2
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 22 interactors: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 HDAC1 HDAC2 JUN MAPK1 PIN1 PRKCA PRKCB PRKCG RB1 SRPK1 SUMO1 SUMO4 TOP2B TP53 XPO1 YWHAE 92 interactors: ANTXR1 APPL1 ARID4A AURKA BRCA1 BRMS1 BRMS1L BUB3 CDC20 CDH1 CDKN1A CDYL CHFR CIR1 CSNK2A1 CSNK2A2 CTBP1 DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 FKBP3 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HOPX HUWE1 IFRD1 IKZF1 IKZF4 ING1 LINC00152 MAD1L1 MBD2 MBD3L2 MEN1 MTA1 MTA2 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 SUV39H1 SYK TFCP2 THRA THRB TOP2A TOP2B TP53 VHL YY1 ZBTB16 ZNF461
Entrez ID 7153 3066
HPRD ID 00536 05521
Ensembl ID ENSG00000131747 ENSG00000196591
Uniprot IDs P11388 Q92769
PDB IDs 1LWZ 1ZXM 1ZXN 4FM9 3MAX 4LXZ 4LY1
Enriched GO Terms of Interacting Partners?
Tagcloud ?
adjacent  adr  adriamycin  allelic  antineoplastic  chimeric  chromatin  close  decondensed  description  disruption  fibers  fish  fluorescence  fusion  hybridization  juxtaposition  metaphase  murine  proximity  rara  rearrangement  resistant  separate  situ  topoisomerase  transcript  truncated 
abnormality  accumbens  ach3  adhd  behavioural  caudate  deficit  disrupted  disruption  dorsal  exploratory  habituation  ht  hydroxytryptamine  hyperactivity  mesocorticolimbic  mesolimbic  modulatory  monoamine  monoaminergic  permanent  putamen  raphe  serotonin  tralpha  tralpha0  trbeta  trs 
Tagcloud (Difference) ?
adjacent  adr  adriamycin  allelic  antineoplastic  chimeric  chromatin  close  decondensed  description  fibers  fish  fluorescence  fusion  hybridization  juxtaposition  metaphase  murine  proximity  rara  rearrangement  resistant  separate  situ  topoisomerase  transcript  truncated 
abnormality  accumbens  ach3  adhd  behavioural  caudate  deficit  disrupted  dorsal  exploratory  habituation  ht  hydroxytryptamine  hyperactivity  mesocorticolimbic  mesolimbic  modulatory  monoamine  monoaminergic  permanent  putamen  raphe  serotonin  tralpha  tralpha0  trbeta  trs 
Tagcloud (Intersection) ?
disruption