TOP2A and DFFB

Number of citations of the paper that reports this interaction (PMID 10959840)
14

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TOP2A	DFFB
Gene Name		topoisomerase (DNA) II alpha 170kDa	DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Nucleus Nucleoplasm Nucleolus Centriole Nucleoid DNA Topoisomerase Complex (ATP-hydrolyzing) Viral Integration Complex Protein Complex	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Drug Binding DNA Binding, Bending Enzyme Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Deoxyribonuclease Activity Enzyme Binding
	Biological Process	Mitotic Cell Cycle Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Topological Change DNA Ligation DNA Unwinding Involved In DNA Replication Mitotic Recombination Cellular Response To DNA Damage Stimulus Chromosome Segregation Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Mitotic DNA Integrity Checkpoint Positive Regulation Of Viral Genome Replication Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription From RNA Polymerase II Promoter	Apoptotic DNA Fragmentation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Apoptotic Chromosome Condensation
Pathways		G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic	Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Programmed Cell Death Apoptotic execution phase
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Lomefloxacin Doxorubicin Norfloxacin Levofloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone
Diseases
GWAS			Blood trace element (Cu levels) ( 23720494)
Protein-Protein Interactions		22 interactors: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 HDAC1 HDAC2 JUN MAPK1 PIN1 PRKCA PRKCB PRKCG RB1 SRPK1 SUMO1 SUMO4 TOP2B TP53 XPO1 YWHAE	4 interactors: APP CIDEB DFFA TOP2A
Entrez ID		7153	1677
HPRD ID		00536	03532
Ensembl ID		ENSG00000131747	ENSG00000169598
Uniprot IDs		P11388	O76075
PDB IDs		1LWZ 1ZXM 1ZXN 4FM9	1IBX
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Cell Cycle Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Response To Growth Factor Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Apoptotic Process Regulation Of Signaling Programmed Cell Death Chromosome Organization Mitotic Cell Cycle Regulation Of Protein Metabolic Process Cell Death Death Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Organelle Organization Response To Wounding Rhythmic Process Response To Stress Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Cell Cycle Checkpoint Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Signal Transduction Cellular Protein Modification Process Blood Coagulation Nucleobase-containing Compound Metabolic Process Immune Response Nucleus Organization Hemostasis Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mitotic Cell Cycle Process Negative Regulation Of Cell Death Peptidyl-threonine Phosphorylation Developmental Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Execution Phase Of Apoptosis Apoptotic Process Programmed Cell Death Cell Death Death Apoptotic Nuclear Changes Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Chromosome Condensation Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Cell Death Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Regulation Of Apoptotic DNA Fragmentation Thymocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Neuron Remodeling Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Embryonic Cleavage DNA Unwinding Involved In DNA Replication Resolution Of Meiotic Recombination Intermediates DNA Ligation T Cell Apoptotic Process Cellular Copper Ion Homeostasis Apoptotic DNA Fragmentation Positive Regulation Of Viral Genome Replication Chromosome Separation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Mitotic Recombination Neuron Maturation MRNA Polyadenylation
Tagcloud ?		adjacent adr adriamycin allelic antineoplastic chimeric chromatin close decondensed description disruption fibers fish fluorescence fusion hybridization juxtaposition metaphase murine proximity rara rearrangement resistant separate situ topoisomerase transcript truncated	100nm 24h 26s 4t1 avenues bortezomib card10 controversial entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2
Tagcloud (Difference) ?		adjacent adr adriamycin allelic antineoplastic chimeric chromatin close decondensed description disruption fibers fish fluorescence fusion hybridization juxtaposition metaphase murine proximity rara rearrangement resistant separate situ topoisomerase transcript truncated	100nm 24h 26s 4t1 avenues bortezomib card10 controversial entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2
Tagcloud (Intersection) ?