TOP2A and TOP2B

Number of citations of the paper that reports this interaction (PMID 8710863)
5

Data Source:
HPRD (in vitro)

		TOP2A	TOP2B
Gene Name		topoisomerase (DNA) II alpha 170kDa	topoisomerase (DNA) II beta 180kDa
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Nucleus Nucleoplasm Nucleolus Centriole Nucleoid DNA Topoisomerase Complex (ATP-hydrolyzing) Viral Integration Complex Protein Complex	Heterochromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nucleoid DNA Topoisomerase Complex (ATP-hydrolyzing)
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Drug Binding DNA Binding, Bending Enzyme Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin Binding Poly(A) RNA Binding Protein Heterodimerization Activity	Chromatin Binding DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Kinase C Binding ATP Binding Protein C-terminus Binding DNA Binding, Bending Enzyme Binding Histone Deacetylase Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Topological Change DNA Ligation DNA Unwinding Involved In DNA Replication Mitotic Recombination Cellular Response To DNA Damage Stimulus Chromosome Segregation Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Mitotic DNA Integrity Checkpoint Positive Regulation Of Viral Genome Replication Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription From RNA Polymerase II Promoter	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Neuron Migration DNA Topological Change DNA Unwinding Involved In DNA Replication Mitotic Recombination Axonogenesis Forebrain Development Mitotic DNA Integrity Checkpoint
Pathways		G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Lomefloxacin Doxorubicin Norfloxacin Levofloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone
Diseases
GWAS
Protein-Protein Interactions		22 interactors: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 HDAC1 HDAC2 JUN MAPK1 PIN1 PRKCA PRKCB PRKCG RB1 SRPK1 SUMO1 SUMO4 TOP2B TP53 XPO1 YWHAE	14 interactors: CD3E CSNK2B ERG HDAC1 HDAC2 MAPK3 RANBP2 RARA SUMO1 TOP2A TOPBP1 TP53 XPO1 XRCC5
Entrez ID		7153	7155
HPRD ID		00536	00537
Ensembl ID		ENSG00000131747	ENSG00000077097
Uniprot IDs		P11388	Q02880 Q59H80
PDB IDs		1LWZ 1ZXM 1ZXN 4FM9	3QX3 4G0U 4G0V 4G0W 4J3N
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Cycle Cell Cycle Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Response To Growth Factor Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Apoptotic Process Regulation Of Signaling Programmed Cell Death Chromosome Organization Mitotic Cell Cycle Regulation Of Protein Metabolic Process Cell Death Death Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of Cell Cycle Negative Regulation Of Cellular Metabolic Process Organelle Organization Response To Wounding Rhythmic Process Response To Stress Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Cell Cycle Checkpoint Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Signal Transduction Cellular Protein Modification Process Blood Coagulation Nucleobase-containing Compound Metabolic Process Immune Response Nucleus Organization Hemostasis Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mitotic Cell Cycle Process Negative Regulation Of Cell Death Peptidyl-threonine Phosphorylation Developmental Process Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Cellular Response To Organic Substance Cellular Response To Stimulus Response To Organic Substance Response To Stimulus Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Localization To Nucleus Cell Differentiation Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Heterocycle Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Aromatic Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Cellular Metabolic Process Response To Drug Cellular Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Fungiform Papilla Formation Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signal Transduction Regulation Of Signaling Fungiform Papilla Morphogenesis Regulation Of Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Positive Regulation Of Receptor Biosynthetic Process Response To Growth Factor Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Fungiform Papilla Development Developmental Process Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process
Tagcloud ?		adjacent adr adriamycin allelic antineoplastic chimeric chromatin close decondensed description disruption fibers fish fluorescence fusion hybridization juxtaposition metaphase murine proximity rara rearrangement resistant separate situ topoisomerase transcript truncated	acylated acylation aglycone antarctica anticarcinogenic antiproliferative cdks chemotherapeutic daunorubicin decosahexaenoic dha ebfr epigenetics ester esters glucoside hdacs iialpha lipase monocytic pdgfr phloretin phloridzin phlorizin regioselective rt2pcr synthesised top2a topoisomerases
Tagcloud (Difference) ?		adjacent adr adriamycin allelic antineoplastic chimeric chromatin close decondensed description disruption fibers fish fluorescence fusion hybridization juxtaposition metaphase murine proximity rara rearrangement resistant separate situ topoisomerase transcript truncated	acylated acylation aglycone antarctica anticarcinogenic antiproliferative cdks chemotherapeutic daunorubicin decosahexaenoic dha ebfr epigenetics ester esters glucoside hdacs iialpha lipase monocytic pdgfr phloretin phloridzin phlorizin regioselective rt2pcr synthesised topoisomerases
Tagcloud (Intersection) ?		top2a