TOP2A and RNF168

Number of citations of the paper that reports this interaction (PubMedID 27558965)
61

Data Source:
BioGRID (enzymatic study)

		TOP2A	RNF168
Description		DNA topoisomerase II alpha	ring finger protein 168
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GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Male Germ Cell Nucleus Nucleus Nucleoplasm Nucleolus Cytoplasm Centriole DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Protein-containing Complex Ribonucleoprotein Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break Catalytic Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding DNA Binding Chromatin Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA DNA Binding, Bending Isomerase Activity Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Protein Heterodimerization Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Histone Ubiquitin Ligase Activity Histone H2AK15 Ubiquitin Ligase Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Metabolic Process DNA Topological Change Chromatin Organization DNA Damage Response Chromosome Segregation Female Meiotic Nuclear Division Chromosome Condensation Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process	DNA Damage Checkpoint Signaling DNA Metabolic Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Radiation Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Double-strand Break Repair Via Classical Nonhomologous End Joining DNA Repair-dependent Chromatin Remodeling
Pathways		Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Norfloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin 13-deoxydoxorubicin RTA 744 Aldoxorubicin ZEN-012 Amrubicin Becatecarin Annamycin Declopramide Finafloxacin
Diseases			RIDDLE syndrome
GWAS		Appendicular lean mass ( 33097823) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Neutrophil percentage of white cells ( 32888494)	Fat distribution (HIV) ( 21897333) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		36 interacting genes: ATM BRCA1 CDK1 CEBPA COPS5 CSNK2A1 DFFB DHX9 FBXO28 GINS1 HDAC1 HDAC2 HNRNPD JUN MAPK1 MDM4 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF10 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I USP7 XPO1 YWHAE	40 interacting genes: ALAS1 ATF6 DGCR8 DHX9 ECPAS H2AC13 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC21 H2BC3 HDAC6 JMJD1C KDM1A KDM4A KMT5A LAPTM5 MACROH2A1 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2G2 UBE2L3 UBE2N USP7 WBP2
Entrez ID		7153	165918
HPRD ID		00536	08190
Ensembl ID		ENSG00000131747	ENSG00000163961
Uniprot IDs		P11388	Q8IYW5
PDB IDs		1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE 6ZY5 6ZY6 6ZY7 6ZY8 8W50	3L11 4GB0 5XIS 5XIT 5XIU 5YDK 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8X7I 8X7J 8X7K 9IPU
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Protein Modification Process Regulation Of RNA Biosynthetic Process Nucleoplasm Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of RNA Metabolic Process PML Body Regulation Of Cell Cycle DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Signal Transduction In Response To DNA Damage Regulation Of DNA Repair DNA Damage Checkpoint Signaling Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Stress Rhythmic Process Presynaptic Cytosol Regulation Of Protein Catabolic Process Postsynaptic Cytosol Regulation Of Proteolysis Mitotic Nuclear Membrane Disassembly Chromatin Organization Regulation Of Proteasomal Protein Catabolic Process	Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Chromatin Organization Protein Ubiquitination Chromatin Remodeling Nucleus Protein Modification Process Structural Constituent Of Chromatin Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Nucleosome Proteolysis Nucleoplasm Regulation Of Gene Expression Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Protein Heterodimerization Activity Negative Regulation Of Gene Expression, Epigenetic Ubiquitin-protein Transferase Activity Negative Regulation Of Gene Expression Enzyme Binding Cellular Response To Stress Ubiquitin Protein Ligase Binding Chromosome Negative Regulation Of Macromolecule Metabolic Process Response To Stress Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Negative Regulation Of Metabolic Process Protein Monoubiquitination Macromolecule Metabolic Process Regulation Of Protein Ubiquitination Heterochromatin Formation Protein K63-linked Ubiquitination Protein-containing Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Damage Response Regulation Of Post-translational Protein Modification Histone H3K9 Demethylase Activity Chromatin DNA Binding Transferase Activity
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