TOP1 and BARD1

Number of citations of the paper that reports this interaction (PMID 12549820)
1

Data Source:
BioGRID (unspecified method)

		TOP1	BARD1
Gene Name		topoisomerase (DNA) I	BRCA1 associated RING domain 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex Perikaryon	Ubiquitin Ligase Complex Nucleus Nucleoplasm Nucleolus Cytoplasm BRCA1-BARD1 Complex Intracellular Membrane-bounded Organelle BRCA1-A Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding DNA Topoisomerase Type I Activity DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Binding Poly(A) RNA Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug	Tissue Homeostasis DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Protein Ubiquitination Negative Regulation Of MRNA 3'-end Processing Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Export From Nucleus Protein K6-linked Ubiquitination
Pathways
Drugs		Irinotecan Topotecan Camptothecin Lucanthone Sodium stibogluconate 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)	Neuroblastoma ( 22941191 21124317) Neuroblastoma (high-risk) ( 19412175)
Protein-Protein Interactions		55 interactors: APAF1 APP ATM BARD1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 GRWD1 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I	107 interactors: ACP1 AKIP1 AP1B1 ASH2L ATP1B1 ATP1B3 BCCIP BCL3 BRCA1 BRD7 BRIP1 CAP1 CASC1 CCDC136 CEP70 CHD3 CNTN4 COL1A1 COMMD1 CRIPAK CSTF1 DCC DDX39B EWSR1 EXOC5 FAM9B FEZ1 FKBP1A FKBP2 FKBP3 FUCA1 GIT1 GOLGA2 GPRASP2 H2AFX HAP1 HIST2H2AC HNRNPC HNRNPLL HSPA14 IDI1 IKBKAP ING5 KAT5 KAT7 KBTBD7 KRT40 LDOC1 LGALS3 LGALS8 LRIF1 MDC1 MRPS22 MSH2 MSH3 MSH6 MT2A ND1 NFKBIA NPC2 OLA1 PCBP2 PDXK PDZD8 PIAS1 PIAS4 POLR2A POLR2H POMZP3 POU2F1 PSMA7 PTN RBBP8 RBMY2BP RPS20 SELENBP1 SETDB1 SMCHD1 SNRNP200 SNX3 SPAG5 SRSF2 TCERG1 TMEM248 TOP1 TP53 TRAF1 TRAPPC11 TRAPPC8 TULP2 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2W UBE3A UBR5 UBXN1 WDR61 XRCC6 ZFP64 ZHX1 ZNF121
Entrez ID		7150	580
HPRD ID		00535	03354
Ensembl ID		ENSG00000198900	ENSG00000138376
Uniprot IDs		P11387	Q99728
PDB IDs		1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8	1JM7 2NTE 2R1Z 3C5R 3FA2
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Apoptotic Process MRNA Metabolic Process MRNA Processing Neuron Apoptotic Process Cellular Response To DNA Damage Stimulus Programmed Cell Death Response To Radiation RNA Processing Cell Death Death Neuron Death Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Chromosome Organization Response To UV DNA Repair Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Response To Light Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated	Cellular Response To DNA Damage Stimulus DNA Repair Protein Polyubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Nitrogen Compound Metabolic Process Double-strand Break Repair DNA Metabolic Process Gene Expression Chromosome Organization Regulation Of Metabolic Process Protein K48-linked Ubiquitination Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Protein Modification By Small Protein Conjugation RNA Biosynthetic Process Transcription, DNA-templated Regulation Of Protein Ubiquitination Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Response To Stress Cell Cycle Checkpoint DNA Recombination Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Protein Ubiquitination Positive Regulation Of Cellular Metabolic Process Meiotic Mismatch Repair Cellular Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleic Acid-templated Transcription Modification-dependent Protein Catabolic Process Chromatin Organization DNA Damage Checkpoint Cellular Macromolecule Catabolic Process Immune System Process Viral Process Cell Cycle Proteolysis Involved In Cellular Protein Catabolic Process Organelle Organization Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription, DNA-templated
Tagcloud ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts	10ng agreed atr belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Difference) ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts	10ng agreed atr belonged biosynthetic biphenyls brca2 dioxin fancd2 figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating
Tagcloud (Intersection) ?