TOP1 and CASP6

Number of citations of the paper that reports this interaction (PMID 9933635)
19

Data Source:
HPRD (in vitro)

		TOP1	CASP6
Gene Name		topoisomerase (DNA) I	caspase 6, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex Perikaryon	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding DNA Topoisomerase Type I Activity DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Binding Poly(A) RNA Binding	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding
	Biological Process	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug	Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Epithelial Cell Differentiation
Pathways			Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Breakdown of the nuclear lamina Caspase-mediated cleavage of cytoskeletal proteins
Drugs		Irinotecan Topotecan Camptothecin Lucanthone Sodium stibogluconate 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)
Protein-Protein Interactions		55 interactors: APAF1 APP ATM BARD1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 GRWD1 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I	38 interactors: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 MAPK6 MAPT NEDD4 NUAK1 PCYT1A PIN1 PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM
Entrez ID		7150	839
HPRD ID		00535	03321
Ensembl ID		ENSG00000198900	ENSG00000138794
Uniprot IDs		P11387	P55212
PDB IDs		1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8	1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Apoptotic Process MRNA Metabolic Process MRNA Processing Neuron Apoptotic Process Cellular Response To DNA Damage Stimulus Programmed Cell Death Response To Radiation RNA Processing Cell Death Death Neuron Death Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Chromosome Organization Response To UV DNA Repair Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Response To Light Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated	Programmed Cell Death Cell Death Death Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Viral Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Tissue Development Response To Stimulus Heart Development Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Cell Communication Regulation Of Protein Kinase Activity Negative Regulation Of Cell Death Regulation Of Apoptotic Process Regulation Of Kinase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Neuron Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Signaling Signaling Regulation Of Cell Death Anatomical Structure Morphogenesis Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Neuron Death Skin Development Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Myeloid Cell Differentiation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Organ Development Cell Differentiation Cellular Response To Stimulus Response To Stress Signal Transduction Positive Regulation Of Catalytic Activity Cell Development Positive Regulation Of Proteolysis Immune System Process Regulation Of Phosphorylation Anatomical Structure Development Cellular Response To Organic Substance
Tagcloud ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts	5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin
Tagcloud (Difference) ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts	5fu aacr abrogating antimetastatic arrests chemoresistance chemoresponse default dissemination disseminative drivers filament hallmark hemidesmosomal itraq junctions phosphorylations phosphorylative prometastatic proteomics reinstate repressing res s25 s38 stathmin stmn1 tethering twin
Tagcloud (Intersection) ?