TOP1 and PPP2R2B

Number of citations of the paper that reports this interaction (PMID 12549820)
1

Data Source:
BioGRID (unspecified method)

		TOP1	PPP2R2B
Gene Name		topoisomerase (DNA) I	protein phosphatase 2, regulatory subunit B, beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex Perikaryon	Protein Phosphatase Type 2A Complex Mitochondrion Mitochondrial Outer Membrane Cytoskeleton
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding DNA Topoisomerase Type I Activity DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Binding Poly(A) RNA Binding	Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug	Apoptotic Process Signal Transduction Regulation Of Catalytic Activity
Pathways
Drugs		Irinotecan Topotecan Camptothecin Lucanthone Sodium stibogluconate 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)	Alcohol dependence ( 19581569) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)
Protein-Protein Interactions		55 interactors: APAF1 APP ATM BARD1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 GRWD1 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I	5 interactors: CHEK2 KLHL15 RAC1 TOP1 TP53
Entrez ID		7150	5521
HPRD ID		00535	05059
Ensembl ID		ENSG00000198900	ENSG00000156475
Uniprot IDs		P11387	Q00005
PDB IDs		1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Apoptotic Process MRNA Metabolic Process MRNA Processing Neuron Apoptotic Process Cellular Response To DNA Damage Stimulus Programmed Cell Death Response To Radiation RNA Processing Cell Death Death Neuron Death Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Chromosome Organization Response To UV DNA Repair Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Response To Light Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated	Regulation Of DNA Replication Replicative Senescence Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Negative Regulation Of DNA Replication Response To Gamma Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cell Aging Viral Process Response To Osmotic Stress Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Signal Transduction Involved In Intra-S DNA Damage Checkpoint Response To Ionizing Radiation Double-strand Break Repair DNA Damage Checkpoint Negative Regulation Of Macromitophagy Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Oligodendrocyte Apoptotic Process Regulation Of Reactive Oxygen Species Metabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Complex Assembly Circadian Rhythm Engulfment Of Apoptotic Cell Negative Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway Apoptotic Process Protein Complex Assembly Mast Cell Chemotaxis DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Embryo Development Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging DNA Conformation Change Mitochondrial DNA Repair Organelle Organization Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment
Tagcloud ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts	allele arg72pro associates curves died ethnically gender genotyped genotypes interested kaplan lifespan lived llis log longevity mdm4 meier rank respective rs1042522 rs1563828 rs2279744 rs319217 rs4245739 snp309 snp31826 snp34091 snps
Tagcloud (Difference) ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts	allele arg72pro associates curves died ethnically gender genotyped genotypes interested kaplan lifespan lived llis log longevity mdm4 meier rank respective rs1042522 rs1563828 rs2279744 rs319217 rs4245739 snp309 snp31826 snp34091 snps
Tagcloud (Intersection) ?