TOP1 and TARBP2

Number of citations of the paper that reports this interaction (PubMedID 12549820)
0

Data Source:
BioGRID (unspecified method)

		TOP1	TARBP2
Description		DNA topoisomerase I	TARBP2 subunit of RISC loading complex
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GO Annotations	Cellular Component	Nuclear Chromosome P-body Fibrillar Center Dense Fibrillar Component Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Protein-DNA Complex Perikaryon	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex Nuclear Body Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding DNA Binding, Bending Isomerase Activity Protein Domain Specific Binding Chromatin DNA Binding Protein-containing Complex Binding Supercoiled DNA Binding	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Binding SiRNA Binding MiRNA Binding Pre-mRNA Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding Protein Sequestering Activity
	Biological Process	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Response To Temperature Stimulus RRNA Transcription Response To Xenobiotic Stimulus Response To Gamma Radiation Programmed Cell Death Peptidyl-serine Phosphorylation Animal Organ Regeneration Circadian Regulation Of Gene Expression Embryonic Cleavage Rhythmic Process Response To CAMP Cellular Response To Luteinizing Hormone Stimulus	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Translation Negative Regulation Of Protein Kinase Activity Spermatid Development Single Fertilization Post-transcriptional Regulation Of Gene Expression SiRNA Processing Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Multicellular Organism Growth Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Skeletal Muscle Tissue Regeneration Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Regulation Of Viral Transcription Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Muscle Cell Differentiation Regulation Of Protein Metabolic Process Neural Precursor Cell Proliferation Protein K63-linked Ubiquitination Regulation Of Regulatory NcRNA Processing Regulation Of SiRNA Processing RISC Complex Assembly Global Gene Silencing By MRNA Cleavage Regulation Of MiRNA Processing
Pathways		SUMOylation of DNA replication proteins	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis PKR-mediated signaling
Drugs		Irinotecan Dactinomycin Doxorubicin Topotecan Camptothecin Edotecarin Lucanthone Elsamitrucin 7-ethyl-10-hydroxycamptothecin Sodium stibogluconate Cositecan XMT-1001 Rubitecan 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE Hexylresorcinol Sacituzumab govitecan Trastuzumab deruxtecan
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 20686565) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol ( 20686565 24097068) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Urate levels ( 31578528) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		59 interacting genes: APAF1 APP ATM BARD1 BRCA1 BRD2 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CEBPA CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 IL7R IRF4 IRF8 IRF9 JAK1 JUN LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PIAS4 PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNW1 SRPK2 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TIAM1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I XRCC5	32 interacting genes: ADARB1 AGO2 APP CDK9 DICER1 EIF2AK2 FOXP1 HDHD2 HSPB1 IKBKG KCNIP3 MAPK8IP2 MED21 NEDD4L NEUROG1 NF2 NKRF NUDT18 OGT PNKP PRKRA RBM14 RNF10 TCEA2 TCEANC TGIF2 TOP1 TRAF4 VAV2 ZMAT3 ZMAT4 ZNF346
Entrez ID		7150	6895
HPRD ID		00535	05446
Ensembl ID		ENSG00000198900	ENSG00000139546
Uniprot IDs		P11387 Q9BVT2	Q15633
PDB IDs		1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8	2CPN 3ADL 3LLH 4WYQ 5N8L 5N8M 5ZAK 5ZAL 5ZAM 6ZBK
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus DNA Damage Response Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Double-strand Break Repair Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Regulation Of RNA Metabolic Process Macromolecule Metabolic Process DNA Repair Response To Ionizing Radiation Response To Radiation Nucleobase-containing Compound Metabolic Process Response To Stress Cellular Response To Ionizing Radiation Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Response To X-ray Regulation Of Programmed Cell Death Regulation Of Metabolic Process Chromatin Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding MRNA Metabolic Process Cellular Response To Radiation Positive Regulation Of Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway DNA Metabolic Process DNA Topoisomerase Binding Nuclear Speck Cellular Developmental Process Positive Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein-RNA Complex Assembly Protein Polyubiquitination	Double-stranded RNA Binding Nucleus Negative Regulation Of Schwann Cell Proliferation RISC-loading Complex SiRNA Processing RISC Complex Assembly SiRNA Binding Regulation Of Primary Metabolic Process Pre-miRNA Processing Regulation Of Macromolecule Metabolic Process Negative Regulation Of Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Nucleic Acid Binding Regulation Of Metabolic Process RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm MiRNA Processing Cell Death Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Translational Initiation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Defense Response To Symbiont Regulation Of RNA Metabolic Process Regulation Of Nervous System Process Defense Response To Other Organism RNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Pre-miRNA Binding Response To External Biotic Stimulus Regulation Of Macromolecule Biosynthetic Process Defense Response Innate Immune Response Response To Other Organism Apoptotic Process Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Metabolic Process Regulation Of Tumor Necrosis Factor Production Nucleolus Regulation Of Programmed Cell Death Endonuclease Activity Regulation Of Developmental Process Response To Stress Negative Regulation Of Cell Population Proliferation Regulation Of Cell Migration
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