TOP1 and RCVRN

Number of citations of the paper that reports this interaction (PMID 12549820)
1

Data Source:
BioGRID (unspecified method)

		TOP1	RCVRN
Gene Name		topoisomerase (DNA) I	recoverin
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex Perikaryon	Dendrite
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding DNA Topoisomerase Type I Activity DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Binding Poly(A) RNA Binding	Calcium Ion Binding Calcium Sensitive Guanylate Cyclase Activator Activity
	Biological Process	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug	Signal Transduction Visual Perception Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Regulation Of Calcium Ion Transport
Pathways			Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction
Drugs		Irinotecan Topotecan Camptothecin Lucanthone Sodium stibogluconate 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)
Protein-Protein Interactions		55 interactors: APAF1 APP ATM BARD1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 GRWD1 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I	11 interactors: ADRBK1 CAV1 GIT2 GRK1 GRK5 GRK6 IL15RA PQBP1 SMAD3 TGFBR2 TOP1
Entrez ID		7150	5957
HPRD ID		00535	01558
Ensembl ID		ENSG00000198900
Uniprot IDs		P11387	P35243 Q53XL0
PDB IDs		1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8	2D8N
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Apoptotic Process MRNA Metabolic Process MRNA Processing Neuron Apoptotic Process Cellular Response To DNA Damage Stimulus Programmed Cell Death Response To Radiation RNA Processing Cell Death Death Neuron Death Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Chromosome Organization Response To UV DNA Repair Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Response To Light Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Phosphorylation Regulation Of The Force Of Heart Contraction By Chemical Signal Tachykinin Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Wound Healing Programmed Cell Death Cell Death Death Phosphate-containing Compound Metabolic Process Regulation Of The Force Of Heart Contraction Receptor Internalization Response To Stimulus Protein Phosphorylation Peptidyl-threonine Phosphorylation Wnt Signaling Pathway Positive Regulation Of Catalytic Activity Embryonic Cranial Skeleton Morphogenesis Signal Transduction Cardiovascular System Development Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Tolerance Induction To Self Antigen Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Receptor-mediated Endocytosis Enzyme Linked Receptor Protein Signaling Pathway Camera-type Eye Development Positive Regulation Of Cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Receptor Metabolic Process Mammary Gland Morphogenesis Eye Development Apoptotic Process Regulation Of Striated Muscle Contraction Negative Regulation Of Cell Death Signaling Organ Morphogenesis Lens Development In Camera-type Eye Positive Regulation Of Hydrolase Activity
Tagcloud ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts
Tagcloud (Difference) ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts
Tagcloud (Intersection) ?