TOP1 and FSHR

Number of citations of the paper that reports this interaction (PMID 15196694)
8

Data Source:
HPRD (two hybrid)

		TOP1	FSHR
Gene Name		topoisomerase (DNA) I	follicle stimulating hormone receptor
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex Perikaryon	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding DNA Topoisomerase Type I Activity DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Binding Poly(A) RNA Binding	Follicle-stimulating Hormone Receptor Activity Protein Binding
	Biological Process	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug	G-protein Coupled Receptor Signaling Pathway Spermatogenesis Female Gamete Generation Gonad Development Male Gonad Development Female Gonad Development Follicle-stimulating Hormone Signaling Pathway
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Irinotecan Topotecan Camptothecin Lucanthone Sodium stibogluconate 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE	Menotropins Follitropin beta Urofollitropin Choriogonadotropin alfa Suramin
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)	Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Erectile dysfunction and prostate cancer treatment ( 20932654) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822)
Protein-Protein Interactions		55 interactors: APAF1 APP ATM BARD1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 GRWD1 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I	20 interactors: ADRBK1 AKT2 APPL1 ARR3 CANX CBX5 FSHB GRK4 GRK6 RNR2 RPS27A S100A10 TOP1 TOP1MT TUG1 UBA52 UBB UBC YWHAQ ZBTB16
Entrez ID		7150	2492
HPRD ID		00535	00639
Ensembl ID		ENSG00000198900	ENSG00000170820
Uniprot IDs		P11387	F5GZW2 P23945
PDB IDs		1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8	1XUN 1XWD 4AY9
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Apoptotic Process MRNA Metabolic Process MRNA Processing Neuron Apoptotic Process Cellular Response To DNA Damage Stimulus Programmed Cell Death Response To Radiation RNA Processing Cell Death Death Neuron Death Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Chromosome Organization Response To UV DNA Repair Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Response To Light Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated	Glycogen Biosynthetic Process Viral Protein Processing Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process Glycogen Metabolic Process Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Polysaccharide Metabolic Process Intracellular Transport Of Virus Regulation Of Cell Cycle Arrest Programmed Cell Death Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Death Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Glucose Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Rhythmic Process Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress Carbohydrate Biosynthetic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 2 Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Toll-like Receptor 9 Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fshrs gonadotrophin lh lhcgr lhcgrs linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Difference) ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts	ancestral arose assigns booroola closely deer distance divergence duplication fecb fecundity fshrs gonadotrophin lh lhcgr lhcgrs linkage mammalian mammals ovine probes recombinants restriction rise sheep today tsh tshr
Tagcloud (Intersection) ?