TOP1 and CKAP5

Number of citations of the paper that reports this interaction (PMID 12549820)
1

Data Source:
BioGRID (unspecified method)

		TOP1	CKAP5
Gene Name		topoisomerase (DNA) I	cytoskeleton associated protein 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex Perikaryon	Spindle Pole Gamma-tubulin Complex Centrosome Cytosol Microtubule Cytoskeleton Membrane Microtubule Plus-end Protein Complex
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Chromatin Binding DNA Topoisomerase Type I Activity DNA Topoisomerase Type II (ATP-hydrolyzing) Activity Protein Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Spindle Organization Mitotic Nuclear Division Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity RNA Transport Centrosome Organization Cell Division
Pathways			Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes
Drugs		Irinotecan Topotecan Camptothecin Lucanthone Sodium stibogluconate 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)	Immunoglobulin A ( 20694011)
Protein-Protein Interactions		55 interactors: APAF1 APP ATM BARD1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 GRWD1 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I	6 interactors: AURKA CACNA1A PTPRN2 TACC1 TOP1 USP19
Entrez ID		7150	9793
HPRD ID		00535	10830
Ensembl ID		ENSG00000198900	ENSG00000175216
Uniprot IDs		P11387	Q14008
PDB IDs		1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Apoptotic Process MRNA Metabolic Process MRNA Processing Neuron Apoptotic Process Cellular Response To DNA Damage Stimulus Programmed Cell Death Response To Radiation RNA Processing Cell Death Death Neuron Death Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Positive Regulation Of Protein Metabolic Process Regulation Of Chromosome Organization Response To UV DNA Repair Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Gene Expression Response To Light Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Transcription, DNA-templated	Cell Division Negative Regulation Of Spindle Checkpoint Cerebellar Molecular Layer Development Vestibular Nucleus Development Spindle Assembly Involved In Female Meiosis I Regulation Of Protein Stability Cell Growth Spindle Assembly Involved In Meiosis Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Regulation Of Microtubule-based Process Gamma-aminobutyric Acid Secretion Spindle Stabilization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cellular Response To Hypoxia Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Cell Cycle Process Rhythmic Synaptic Transmission Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Oocyte Maturation Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Meiotic Spindle Organization Positive Regulation Of Cell Cycle Protein Localization To Centrosome Mitotic Centrosome Separation Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Female Meiosis I Positive Regulation Of Oocyte Development Centrosome Separation Negative Regulation Of Hormone Biosynthetic Process Pons Development Embryonic Cleavage Regulation Of Protein Catabolic Process Cerebellar Purkinje Cell Differentiation Interkinetic Nuclear Migration Organelle Localization Cerebellar Purkinje Cell Layer Morphogenesis Protein Localization To Cytoskeleton Histone-serine Phosphorylation Microtubule Cytoskeleton Organization Regulation Of Spindle Checkpoint Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Skeletal Muscle Tissue Development Reflex Behavioral Response To Pain Neurogenesis Regulation Of Cell Cycle Process
Tagcloud ?		anucleate catalytically complements dispensable division evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts	abscission binucleated bridges centrosome chfr coil coiled converges cytokinetic division envelope epistatically explanations fam161b interactome interactors localize lymphangioleiomyomatosis players poles purify ser939 tacc tacc3 tog tsc tsc1 tsc2 tuberous
Tagcloud (Difference) ?		anucleate catalytically complements dispensable evolutionarily homologs hypersensitive inviability inviable lethal mitosis permissive pombe probable proper restrictive schizosaccharomyces searches semi synthetically thiabendazole top1p topoisomerase trf4 trf4p trf5 trf5p ts	abscission binucleated bridges centrosome chfr coil coiled converges cytokinetic envelope epistatically explanations fam161b interactome interactors localize lymphangioleiomyomatosis players poles purify ser939 tacc tacc3 tog tsc tsc1 tsc2 tuberous
Tagcloud (Intersection) ?		division