TNNI3 and HSPB2

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		TNNI3	HSPB2
Description		troponin I3, cardiac type	heat shock protein family B (small) member 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Troponin Complex Myofibril Sarcomere Contractile Muscle Fiber Cardiac Myofibril Cardiac Troponin Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Calcium-dependent Protein Binding Actin Filament Binding	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Intracellular Calcium Ion Homeostasis Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Striated Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATP-dependent Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process
Pathways		Striated Muscle Contraction Ion homeostasis
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Monocyte count ( 32888494) Platelet count ( 32888494)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RASSF10 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335
Entrez ID		7137	3316
HPRD ID		11769	03712
Ensembl ID		ENSG00000129991	ENSG00000170276
Uniprot IDs		P19429 Q6FGX2	A8KAH6 Q16082
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI 7SC2 7SC3 7SUP 7SVC 7SWG 7SWI 7SXC 7SXD 7UH9 7UHA 7UTI 7UTL 8DZV 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT	6F2R
Enriched GO Terms of Interacting Partners?		Troponin Complex Regulation Of Muscle System Process Troponin I Binding Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Regulation Of System Process Striated Muscle Contraction Cardiac Troponin Complex Skeletal Muscle Contraction Troponin T Binding Transition Between Fast And Slow Fiber Sarcomere Striated Muscle Thin Filament Response To Water Cytoskeletal Protein Binding Regulation Of Skeletal Muscle Adaptation System Process Contractile Muscle Fiber Tropomyosin Binding Actinin Binding Muscle Alpha-actinin Binding Muscle Filament Sliding Cation Channel Complex Actin-myosin Filament Sliding Spinal Cord Development Non-motile Cilium Monoatomic Cation Channel Activity Sodium Channel Activity Metanephric Cortical Collecting Duct Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Sodium Ion Transport Metanephric Cortex Development Metanephric Distal Tubule Development Regulation Of Muscle Filament Sliding Speed Actin-mediated Cell Contraction Cardiac Muscle Contraction Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Sour Taste Receptor Activity Detection Of Mechanical Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Response To Mechanical Stimulus Ciliary Membrane Mast Cell Secretory Granule Organization Polycystin Complex Protein Homotetramerization Metanephric Smooth Muscle Tissue Development Mesenchyme Development	Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?