HSPB2 and ATP6V1E1

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	ATP6V1E1
Description		heat shock protein family B (small) member 2	ATPase H+ transporting V1 subunit E1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Vacuolar Proton-transporting V-type ATPase, V1 Domain Cytoplasm Lysosomal Membrane Endosome Cytosol Plasma Membrane Microvillus Membrane Apical Plasma Membrane Proton-transporting Two-sector ATPase Complex Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Proton-transporting Two-sector ATPase Complex, Catalytic Domain Synapse Extracellular Exosome
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Monoatomic Ion Transport Regulation Of Macroautophagy Synaptic Vesicle Lumen Acidification Proton Transmembrane Transport
Pathways			ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy
Drugs			Tiludronic acid
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	14 interacting genes: ALDOA ALDOB ALDOC APP ATP6V0E1 ATP6V1G1 ATP6V1G2 ATP6V1H HSPB2 MESD NHERF1 SOS1 TRAF6 XRCC6
Entrez ID		3316	529
HPRD ID		03712	00163
Ensembl ID		ENSG00000170276	ENSG00000131100
Uniprot IDs		A8KAH6 Q16082	P36543 Q53Y06
PDB IDs		6F2R	6WLZ 6WM2 6WM3 6WM4 7U4T 7UNF
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	Fructose-bisphosphate Aldolase Activity Proton-transporting ATPase Activity, Rotational Mechanism Fructose 1,6-bisphosphate Metabolic Process Homeostatic Process Vacuolar Proton-transporting V-type ATPase, V1 Domain Fructose Metabolic Process Extrinsic Component Of Synaptic Vesicle Membrane Cellular Homeostasis Proton-transporting V-type ATPase Complex ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Lyase Activity Glycolytic Process Growth Factor Receptor Binding Proton Transmembrane Transport ADP Metabolic Process Nucleoside Diphosphate Catabolic Process Fructose Binding Ribonucleoside Diphosphate Catabolic Process Regulation Of Macroautophagy Pyruvate Metabolic Process Cytoskeletal Protein Binding Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Nucleotide Catabolic Process Intracellular Chemical Homeostasis Vacuolar Proton-transporting V-type ATPase Complex Regulation Of Phosphorus Metabolic Process Nucleotide Catabolic Process Synaptic Vesicle Lumen Acidification Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Secretory Granule Lumen Ficolin-1-rich Granule Lumen Nucleoside Phosphate Catabolic Process Fc-epsilon Receptor Signaling Pathway ATP Hydrolysis Activity Regulation Of Autophagy Low-density Lipoprotein Particle Receptor Binding Monoatomic Cation Transport Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis ATP Metabolic Process Hexose Metabolic Process Organophosphate Catabolic Process Clathrin-coated Vesicle Membrane Cytosol Monosaccharide Metabolic Process Vacuolar Acidification
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