HSPB2 and MDH1

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	MDH1
Description		heat shock protein family B (small) member 2	malate dehydrogenase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Space Cytoplasm Centrosome Cytosol Extracellular Exosome
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	Catalytic Activity Malic Enzyme Activity Protein Binding Oxidoreductase Activity Malate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor L-malate Dehydrogenase (NAD+) Activity Diiodophenylpyruvate Reductase (NAD+) Activity (2R)-hydroxyphenylpyruvate Reductase [NAD(P)H] Activity
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADP+ Metabolic Process NAD+ Metabolic Process Carboxylic Acid Metabolic Process Malate-aspartate Shuttle
Pathways			Malate-aspartate shuttle
Drugs			NADH Nicotinamide adenine dinucleotide phosphate Artenimol
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Asthma and attention deficit hyperactivity disorder ( 31619474) Blood protein levels ( 30072576) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	15 interacting genes: CDC42 CHRM2 EGFR ERBB2 FUS GPD1 HSD17B10 HSPB2 LTB4R2 MPP3 SERPINB5 TERF1 TERF2IP TP53 TTC3
Entrez ID		3316	4190
HPRD ID		03712	01100
Ensembl ID		ENSG00000170276	ENSG00000014641
Uniprot IDs		A8KAH6 Q16082	A0A5K1VW95 P40925 V9HWF2
PDB IDs		6F2R	7RM9 7RRL
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	Negative Regulation Of Telomere Maintenance Shelterin Complex Regulation Of DNA Metabolic Process ERBB2-EGFR Signaling Pathway Nuclear Telomere Cap Complex Negative Regulation Of Chromosome Organization Telomere Capping G-rich Strand Telomeric DNA Binding Regulation Of Phosphorus Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase ERBB2 Signaling Pathway Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Replication RNA-templated DNA Biosynthetic Process Regulation Of Epithelial Cell Proliferation Gland Morphogenesis Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cell Growth Regulation Of Cell Growth Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Organelle Organization Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Multivesicular Body, Internal Vesicle Lumen Molecular Condensate Scaffold Activity Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Regulation Of Cellular Response To Stress Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Repair
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