HSPB2 and MYBPC3

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	MYBPC3
Description		heat shock protein family B (small) member 2	myosin binding protein C3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere M Band A Band Myosin Filament Cardiac Myofibril
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	ATPase Activator Activity Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Regulation Of Muscle Filament Sliding Sarcomere Organization Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Regulation Of Cardiac Muscle Cell Contraction
Pathways			Striated Muscle Contraction
Drugs
Diseases			Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)
GWAS		Hip circumference adjusted for BMI ( 34021172)	Alcohol consumption ( 31358974) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Experiencing mood swings ( 29500382) Fruit consumption ( 32066663) HDL cholesterol levels ( 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Intraocular pressure ( 30054594) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) Neuroticism ( 29255261) Pulse pressure ( 30578418) Refractive error ( 32231278) Thrombin generation potential phenotypes ( 24357727) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	8 interacting genes: CAPN1 HSPB2 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN
Entrez ID		3316	4607
HPRD ID		03712	02980
Ensembl ID		ENSG00000170276	ENSG00000134571
Uniprot IDs		A8KAH6 Q16082	A5YM48 Q14896
PDB IDs		6F2R	1GXE 1PD6 2AVG 2K1M 2MQ0 2MQ3 2V6H 3CX2 5K6P 6CXI 6CXJ 6G2T 7LRG 7TIJ 7TIT 7TJ7 8G4L
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	M Band Cytoplasm Uropod Organization Actin-mediated Cell Contraction Cortical Granule Exocytosis Actin Filament-based Movement Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Neutrophil-mediated Killing Of Fungus Cytoplasmic Side Of Plasma Membrane Myosin II Filament Actomyosin Structure Organization Skeletal Muscle Myosin Thick Filament Assembly Bundle Of His Cell To Purkinje Myocyte Communication Neutrophil-mediated Killing Of Gram-positive Bacterium Calpain Complex Somatic Muscle Development Actomyosin Contractile Ring Myosin Filament Assembly Z Disc Phagolysosome Mammary Gland Involution Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Peptidyl-serine Autophosphorylation Skeletal Muscle Atrophy NMDA Selective Glutamate Receptor Signaling Pathway Actin Filament Binding Regulation Of Plasma Membrane Repair Establishment Of Meiotic Spindle Localization Calmodulin Binding Establishment Of T Cell Polarity Detection Of Muscle Stretch Muscle Contraction Striated Muscle Thin Filament Telethonin Binding Skeletal Muscle Thin Filament Assembly Defense Response To Other Organism Diapedesis Innate Immune Response Defense Response To Symbiont Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Respiratory Burst Involved In Defense Response Cellular Response To Testosterone Stimulus
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