HSPB2 and PPM1K

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	PPM1K
Description		heat shock protein family B (small) member 2	protein phosphatase, Mg2+/Mn2+ dependent 1K
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Mitochondrial Matrix
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Manganese Ion Binding Cation Binding Metal Ion Binding [3-methyl-2-oxobutanoate Dehydrogenase (lipoamide)]-phosphatase Activity
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Branched-chain Amino Acid Catabolic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Intracellular Signal Transduction
Pathways			Branched-chain amino acid catabolism H139Hfs13* PPM1K causes a mild variant of MSUD
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Branched-chain amino acid levels (Isoleucine) ( 27898682) Branched-chain amino acid levels (Leucine) ( 27898682) Branched-chain amino acid levels (Valine) ( 27898682) Coffee consumption (cups per day) ( 25288136) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Metabolite levels ( 22286219 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 32514006)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	14 interacting genes: AATK BIRC2 ERBB3 HSF2BP HSPB2 LMTK2 MAGEA11 MYB MYO15B NTAQ1 PTK7 UBXN11 XIAP ZNF410
Entrez ID		3316	152926
HPRD ID		03712	15167
Ensembl ID		ENSG00000170276	ENSG00000163644
Uniprot IDs		A8KAH6 Q16082	Q8N3J5
PDB IDs		6F2R	2IQ1 4DA1 6AK7
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Polyubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Neuron Apoptotic Process Regulation Of Protein Polyubiquitination
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