TNNI3 and PKD2L1

Number of citations of the paper that reports this interaction (PubMedID 12809519)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TNNI3	PKD2L1
Description		troponin I3, cardiac type	polycystin 2 like 1, transient receptor potential cation channel
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GO Annotations	Cellular Component	Cytoplasm Cytosol Troponin Complex Myofibril Sarcomere Contractile Muscle Fiber Cardiac Myofibril Cardiac Troponin Complex	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cilium Cell Surface Actin Cytoskeleton Membrane Cytoplasmic Vesicle Cation Channel Complex Calcium Channel Complex Cell Projection Receptor Complex Ciliary Membrane Non-motile Cilium
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Calcium-dependent Protein Binding Actin Filament Binding	Calcium-activated Cation Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Monoatomic Cation Transmembrane Transporter Activity Calcium-activated Potassium Channel Activity Sour Taste Receptor Activity Identical Protein Binding Actinin Binding Transmembrane Transporter Binding Metal Ion Binding Metal Ion Transmembrane Transporter Activity Muscle Alpha-actinin Binding Alpha-actinin Binding PH-gated Monoatomic Ion Channel Activity Osmolarity-sensing Monoatomic Cation Channel Activity
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Intracellular Calcium Ion Homeostasis Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Striated Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATP-dependent Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Smoothened Signaling Pathway Response To Water Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Detection Of Chemical Stimulus Involved In Sensory Perception Of Taste Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Protein Tetramerization Protein Homotetramerization Calcium Ion Transmembrane Transport Cellular Response To PH Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport
Pathways		Striated Muscle Contraction Ion homeostasis
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Monocyte count ( 32888494) Platelet count ( 32888494)	A body shape index ( 34021172) Coronary artery disease ( 33020668 29212778) Diastolic blood pressure ( 30224653) Fatty acid desaturase activity (adipose tissue) ( 30453627) Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Macular thickness ( 30535121) Mean platelet volume ( 27863252 32888494) Obesity-related traits ( 23251661) Palmitic acid (16:0) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293) Phospholipid levels (plasma) ( 22359512) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 24625756 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Squamous cell lung carcinoma ( 28604730) Vaccenic acid (18:1n-7) levels ( 28298293)
Interacting Genes		19 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RASSF10 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	4 interacting genes: CLDN19 TNNI1 TNNI2 TNNI3
Entrez ID		7137	9033
HPRD ID		11769	16063
Ensembl ID		ENSG00000129991	ENSG00000107593
Uniprot IDs		P19429 Q6FGX2	Q1L4F0 Q9P0L9
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI 7SC2 7SC3 7SUP 7SVC 7SWG 7SWI 7SXC 7SXD 7UH9 7UHA 7UTI 7UTL 8DZV 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT	3TE3 4GIF 6DU8
Enriched GO Terms of Interacting Partners?		Troponin Complex Regulation Of Muscle System Process Troponin I Binding Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Regulation Of System Process Striated Muscle Contraction Cardiac Troponin Complex Skeletal Muscle Contraction Troponin T Binding Transition Between Fast And Slow Fiber Sarcomere Striated Muscle Thin Filament Response To Water Cytoskeletal Protein Binding Regulation Of Skeletal Muscle Adaptation System Process Contractile Muscle Fiber Tropomyosin Binding Actinin Binding Muscle Alpha-actinin Binding Muscle Filament Sliding Cation Channel Complex Actin-myosin Filament Sliding Spinal Cord Development Non-motile Cilium Monoatomic Cation Channel Activity Sodium Channel Activity Metanephric Cortical Collecting Duct Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Sodium Ion Transport Metanephric Cortex Development Metanephric Distal Tubule Development Regulation Of Muscle Filament Sliding Speed Actin-mediated Cell Contraction Cardiac Muscle Contraction Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Sour Taste Receptor Activity Detection Of Mechanical Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Response To Mechanical Stimulus Ciliary Membrane Mast Cell Secretory Granule Organization Polycystin Complex Protein Homotetramerization Metanephric Smooth Muscle Tissue Development Mesenchyme Development	Troponin Complex Skeletal Muscle Contraction Cardiac Muscle Contraction Troponin T Binding Striated Muscle Contraction Muscle Contraction Muscle System Process Actin Binding Ventricular Cardiac Muscle Tissue Morphogenesis System Process Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Regulation Of Striated Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Mesaxon Regulation Of Muscle Contraction Cardiac Troponin Complex Troponin C Binding Regulation Of Transepithelial Transport Regulation Of Muscle System Process Transition Between Fast And Slow Fiber Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cardiac Myofibril Apical Junction Assembly Paracellular Tight Junction Channel Activity Retinal Pigment Epithelium Development Paracellular Transport Paranodal Junction Regulation Of Skeletal Muscle Adaptation Schmidt-Lanterman Incisure Action Potential Propagation Neuronal Action Potential Propagation Negative Regulation Of ATP-dependent Activity Tissue Morphogenesis Actin Filament-based Process Contractile Muscle Fiber Calcium Channel Inhibitor Activity Muscle Filament Sliding Actin-myosin Filament Sliding Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Heart Contraction Regulation Of System Process Apical Junction Complex Heart Process Regulation Of ATP-dependent Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cell-cell Adhesion Mediator Activity Tight Junction Actin-mediated Cell Contraction Renal Absorption
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