TNNI3 and PKD2L1

Number of citations of the paper that reports this interaction (PMID 12809519)
4

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		TNNI3	PKD2L1
Gene Name		troponin I type 3 (cardiac)	polycystic kidney disease 2-like 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex Sarcomere	Endoplasmic Reticulum Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Nonmotile Primary Cilium Calcium Channel Complex Intracellular Membrane-bounded Organelle Receptor Complex Ciliary Membrane
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding	Calcium Activated Cation Channel Activity Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cation Transmembrane Transporter Activity Calcium-activated Potassium Channel Activity Sour Taste Receptor Activity Identical Protein Binding Muscle Alpha-actinin Binding Alpha-actinin Binding
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Heart Development Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Cation Transport Smoothened Signaling Pathway Sodium Ion Transmembrane Transport Sensory Perception Of Sour Taste Detection Of Mechanical Stimulus Protein Homotrimerization Calcium Ion Transmembrane Transport Cellular Response To Acidic PH Potassium Ion Transmembrane Transport
Pathways		Striated Muscle Contraction
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS			Obesity-related traits ( 23251661) Palmitic acid (16:0) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 22359512)
Protein-Protein Interactions		14 interactors: ACTA1 LYST PAPPA PKD2 PKD2L1 PRKCA RCAN3 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	3 interactors: TNNI1 TNNI2 TNNI3
Entrez ID		7137	9033
HPRD ID		11769	16063
Ensembl ID		ENSG00000129991	ENSG00000107593
Uniprot IDs		P19429 Q6FGX2	Q1L4F0 Q9P0L9
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R	3TE3 4GIF
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Skeletal Muscle Contraction Musculoskeletal Movement Movement Of Cell Or Subcellular Component Negative Regulation Of ATPase Activity Skeletal Muscle Adaptation Striated Muscle Contraction Actin Filament-based Process Muscle Tissue Development Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Inorganic Substance Detection Of Abiotic Stimulus Ion Homeostasis Response To Mechanical Stimulus Regulation Of ATPase Activity Heart Morphogenesis Response To Abiotic Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Detection Of Mechanical Stimulus Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Endothelial Cell Migration Muscle Organ Development Positive Regulation Of Endothelial Cell Proliferation Cellular Calcium Ion Homeostasis Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Regulation Of Muscle Filament Sliding Speed Positive Regulation Of Dense Core Granule Biogenesis Muscle Tissue Morphogenesis Calcium Ion Homeostasis Striated Muscle Tissue Development Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Response To Metal Ion Myofibril Assembly Positive Regulation Of Epithelial Cell Migration Response To Interleukin-1 Regulation Of Endothelial Cell Proliferation Protein Kinase D Signaling Metanephric Smooth Muscle Tissue Development Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Skeletal Muscle Fiber Adaptation	Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Regulation Of Muscle Contraction Muscle Contraction Muscle System Process Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Actin Filament-based Process Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Striated Muscle Contraction Cardiac Ventricle Development Cardiac Chamber Development Cardiac Muscle Tissue Development Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Movement Of Cell Or Subcellular Component Heart Morphogenesis Muscle Organ Development Striated Muscle Tissue Development Muscle Tissue Development Negative Regulation Of ATPase Activity Muscle Structure Development Heart Development Tissue Morphogenesis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Skeletal Muscle Contraction Cardiovascular System Development Regulation Of ATPase Activity Organ Morphogenesis Musculoskeletal Movement Cardiac Muscle Contraction Regulation Of Smooth Muscle Contraction Heart Contraction Regulation Of Striated Muscle Contraction Regulation Of Systemic Arterial Blood Pressure Vasculogenesis Tissue Development Regulation Of Blood Pressure
Tagcloud ?		activin bmp4 cardiomyogenic discovering dish enthusiasm exploiting hesc hipsc homeodomain homogeneity hpscs implement iroquois irx irx4 mlc2a mlc2v myosin offering passaged pluripotent repairing robustly standardization subpopulation technically tnnt2 troponin
Tagcloud (Difference) ?		activin bmp4 cardiomyogenic discovering dish enthusiasm exploiting hesc hipsc homeodomain homogeneity hpscs implement iroquois irx irx4 mlc2a mlc2v myosin offering passaged pluripotent repairing robustly standardization subpopulation technically tnnt2 troponin
Tagcloud (Intersection) ?