HSPB2 and DUSP1

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	DUSP1
Description		heat shock protein family B (small) member 2	dual specificity phosphatase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Growth Factor Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Endoderm Formation Negative Regulation Of Cell Adhesion Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Light Stimulus Response To Estradiol Response To Retinoic Acid Cellular Response To Hormone Stimulus Response To Testosterone Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Response To Glucocorticoid Negative Regulation Of Meiotic Cell Cycle Response To CAMP Response To Calcium Ion Peptidyl-serine Dephosphorylation ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Monocyte Chemotaxis Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of P38MAPK Cascade Cellular Response To Chemokine Negative Regulation Of DNA Biosynthetic Process
Pathways			RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	C-reactive protein levels ( 30388399) Diastolic blood pressure ( 30224653) Inflammatory bowel disease ( 26192919) Metabolite levels ( 23823483) Offspring birth weight ( 31043758) Optic cup area ( 28073927) Ulcerative colitis ( 26192919) Vertical cup-disc ratio ( 25241763 28073927 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	15 interacting genes: AATK CKS1B HSPA4 HSPB2 MAPK1 MAPK12 MAPK14 MAPK3 MAPK8 MAPT POLR1H ROR2 SKP2 STAMBPL1 UBB
Entrez ID		3316	1843
HPRD ID		03712	02835
Ensembl ID		ENSG00000170276	ENSG00000120129
Uniprot IDs		A8KAH6 Q16082	B4DU40 P28562
PDB IDs		6F2R	6APX 6D65 6D66 6D67
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Protein Kinase Activity Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Protein Serine Kinase Activity Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Cyclase Activity MAPK Cascade Interleukin-34-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Golgi Inheritance ATP Binding Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Cellular Response To Starvation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Energy Homeostasis DNA Damage Response Nucleotide Binding Bergmann Glial Cell Differentiation Response To Starvation Response To Nutrient Levels Response To Stress Cellular Response To Nutrient Levels Cellular Response To Tumor Necrosis Factor Regulation Of Golgi Organization Pseudopodium Regulation Of Early Endosome To Late Endosome Transport Response To Lipopolysaccharide Schwann Cell Development Response To Growth Factor Positive Regulation Of Macrophage Chemotaxis Regulation Of Ossification Response To Tumor Necrosis Factor Response To Molecule Of Bacterial Origin Face Development Positive Regulation Of Neuroinflammatory Response Peptidyl-threonine Phosphorylation Animal Organ Formation Cellular Response To Stress ERBB2 Signaling Pathway Mitochondrion Transport Along Microtubule Positive Regulation Of Macrophage Migration
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