HSPB2 and ALDOA

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	ALDOA
Description		heat shock protein family B (small) member 2	aldolase, fructose-bisphosphate A
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Actin Cytoskeleton Membrane Platelet Alpha Granule Lumen M Band I Band Secretory Granule Lumen Sperm Head Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	RNA Binding Actin Binding Fructose-bisphosphate Aldolase Activity Protein Binding Cytoskeletal Protein Binding Tubulin Binding Lyase Activity Identical Protein Binding Cadherin Binding Fructose Binding
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Fructose Metabolic Process Glycolytic Process ATP Biosynthetic Process Striated Muscle Contraction Actin Filament Organization Binding Of Sperm To Zona Pellucida Regulation Of Cell Shape Fructose 1,6-bisphosphate Metabolic Process Muscle Cell Cellular Homeostasis Protein Homotetramerization
Pathways			Platelet degranulation Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs			Zinc 1,6-Fructose Diphosphate (Linear Form) Dihydroxyacetone phosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Plateletcrit ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	37 interacting genes: ADRB2 ATP6V1E1 BCAT2 CACNA1A CEBPA CYTH2 DSCR9 DYNLL1 ENO1 ENO3 ERBB2 ERBB3 ERBB4 FANCA GALNT6 GPD2 HSD17B10 HSPB2 IFNA4 LCOR LINC01554 MLH1 MYOC NXF1 OGT PCNA PIAS4 PLD2 SHANK3 SLC22A1 SRPK2 SUMO4 TERF1 TGM2 TRIM63 TUBB XRN1
Entrez ID		3316	226
HPRD ID		03712	00070
Ensembl ID		ENSG00000170276	ENSG00000149925
Uniprot IDs		A8KAH6 Q16082	P04075 V9HWN7
PDB IDs		6F2R	1ALD 2ALD 4ALD 5KY6 6XMH 6XML 6XMM 6XMO
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	ERBB2 Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB3:ERBB2 Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Basal Plasma Membrane Neuregulin Receptor Activity Negative Regulation Of DNA Metabolic Process ERBB Signaling Pathway Isoleucine Metabolic Process L-isoleucine Catabolic Process ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Adaptation Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation ERBB4 Signaling Pathway Telomere Localization Gluconeogenesis Hexose Biosynthetic Process Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Response To Stress Regulation Of Small GTPase Mediated Signal Transduction Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Regulation Of DNA Metabolic Process Receptor Complex Regulation Of Purine Nucleotide Metabolic Process Canonical Glycolysis Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of DNA Biosynthetic Process Dopamine Transport Brown Fat Cell Differentiation Positive Regulation Of Excitatory Postsynaptic Potential Import Into Cell Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Protein-containing Complex Binding Positive Regulation Of Mini Excitatory Postsynaptic Potential Branched-chain Amino Acid Metabolic Process Branched-chain Amino Acid Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glycolytic Process Through Glucose-6-phosphate M Band Nicotinamide Nucleotide Metabolic Process
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