TNNI3 and MST1

Number of citations of the paper that reports this interaction (PubMedID 18986304)
37

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, two hybrid)

		TNNI3	MST1
Description		troponin I3, cardiac type	macrophage stimulating 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Troponin Complex Myofibril Sarcomere Contractile Muscle Fiber Cardiac Myofibril Cardiac Troponin Complex	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Calcium-dependent Protein Binding Actin Filament Binding	Endopeptidase Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Intracellular Calcium Ion Homeostasis Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Striated Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATP-dependent Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Proteolysis Negative Regulation Of Gluconeogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Macromolecule Metabolic Process Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Striated Muscle Contraction Ion homeostasis	Signaling by MST1
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Monocyte count ( 32888494) Platelet count ( 32888494)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 17554300 28067908 17554261 18587394 21102463) Extremely high intelligence ( 29520040) Feeling miserable ( 29500382) Inflammatory bowel disease ( 23128233 28067908) Primary sclerosing cholangitis ( 27992413 21151127 23603763) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 20228799 28067908 25082827 19915572 21297633)
Interacting Genes		19 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RASSF10 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	10 interacting genes: BECN1 FOXO1 KLKB1 MOB1A MST1R RASSF1 SERPINA3 TNNC1 TNNI3 TNNT2
Entrez ID		7137	4485
HPRD ID		11769	00798
Ensembl ID		ENSG00000129991	ENSG00000173531
Uniprot IDs		P19429 Q6FGX2	G3XAK1 P26927 Q53GN8
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI 7SC2 7SC3 7SUP 7SVC 7SWG 7SWI 7SXC 7SXD 7UH9 7UHA 7UTI 7UTL 8DZV 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT	2ASU 4QT8
Enriched GO Terms of Interacting Partners?		Troponin Complex Regulation Of Muscle System Process Troponin I Binding Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Regulation Of System Process Striated Muscle Contraction Cardiac Troponin Complex Skeletal Muscle Contraction Troponin T Binding Transition Between Fast And Slow Fiber Sarcomere Striated Muscle Thin Filament Response To Water Cytoskeletal Protein Binding Regulation Of Skeletal Muscle Adaptation System Process Contractile Muscle Fiber Tropomyosin Binding Actinin Binding Muscle Alpha-actinin Binding Muscle Filament Sliding Cation Channel Complex Actin-myosin Filament Sliding Spinal Cord Development Non-motile Cilium Monoatomic Cation Channel Activity Sodium Channel Activity Metanephric Cortical Collecting Duct Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Sodium Ion Transport Metanephric Cortex Development Metanephric Distal Tubule Development Regulation Of Muscle Filament Sliding Speed Actin-mediated Cell Contraction Cardiac Muscle Contraction Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Sour Taste Receptor Activity Detection Of Mechanical Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Response To Mechanical Stimulus Ciliary Membrane Mast Cell Secretory Granule Organization Polycystin Complex Protein Homotetramerization Metanephric Smooth Muscle Tissue Development Mesenchyme Development	Cardiac Troponin Complex Troponin Complex Muscle Filament Sliding Actin-myosin Filament Sliding Regulation Of Muscle System Process Troponin C Binding Actin-mediated Cell Contraction Troponin I Binding Troponin T Binding Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Sarcomere Cardiac Muscle Tissue Morphogenesis Actin Filament-based Movement Cardiac Myofibril Regulation Of System Process Muscle Tissue Morphogenesis Striated Muscle Contraction Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Regulation Of Muscle Contraction Regulation Of ATP-dependent Activity Skeletal Muscle Contraction Muscle Contraction Muscle System Process Regulation Of Muscle Filament Sliding Speed Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cellular Response To Aluminum Ion Regulation Of Cardiac Muscle Hypertrophy Response To Metal Ion Positive Regulation Of Protein Metabolic Process Calcium-dependent Protein Binding Factor XII Activation Macrophage Colony-stimulating Factor Receptor Activity Tissue Morphogenesis Actin Filament-based Process Diaphragm Contraction Regulation Of Muscle Filament Sliding Response To Aluminum Ion Positive Regulation Of Fibrinolysis Macrophage Colony-stimulating Factor Signaling Pathway Involuntary Skeletal Muscle Contraction Phosphatidylinositol 3-kinase Complex, Class III, Type II Negative Regulation Of Lysosome Organization Cellular Response To Oxygen-glucose Deprivation Phosphatidylinositol 3-kinase Complex, Class III, Type I Regulation Of Multicellular Organismal Process Cellular Response To Hyperoxia Cytoplasmic Side Of Mitochondrial Outer Membrane Response To Mitochondrial Depolarisation
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