TNNI3 and TNNI3K

Number of citations of the paper that reports this interaction (PMID 12721663)
9

Data Source:
HPRD (in vivo, two hybrid)

		TNNI3	TNNI3K
Gene Name		troponin I type 3 (cardiac)	TNNI3 interacting kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex Sarcomere	Nucleus Cytoplasm
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Troponin I Binding Metal Ion Binding
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Heart Development Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Protein Phosphorylation
Pathways		Striated Muscle Contraction
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS			Body mass index ( 23669352 20935630) Obesity ( 23563607) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		14 interactors: ACTA1 LYST PAPPA PKD2 PKD2L1 PRKCA RCAN3 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	7 interactors: ACTA1 ACTC1 AIP FABP3 HADHB MYBPC3 TNNI3
Entrez ID		7137	51086
HPRD ID		11769	18208
Ensembl ID		ENSG00000129991	ENSG00000116783
Uniprot IDs		P19429 Q6FGX2	Q59H18
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Skeletal Muscle Contraction Musculoskeletal Movement Movement Of Cell Or Subcellular Component Negative Regulation Of ATPase Activity Skeletal Muscle Adaptation Striated Muscle Contraction Actin Filament-based Process Muscle Tissue Development Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Inorganic Substance Detection Of Abiotic Stimulus Ion Homeostasis Response To Mechanical Stimulus Regulation Of ATPase Activity Heart Morphogenesis Response To Abiotic Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Detection Of Mechanical Stimulus Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Endothelial Cell Migration Muscle Organ Development Positive Regulation Of Endothelial Cell Proliferation Cellular Calcium Ion Homeostasis Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Regulation Of Muscle Filament Sliding Speed Positive Regulation Of Dense Core Granule Biogenesis Muscle Tissue Morphogenesis Calcium Ion Homeostasis Striated Muscle Tissue Development Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Response To Metal Ion Myofibril Assembly Positive Regulation Of Epithelial Cell Migration Response To Interleukin-1 Regulation Of Endothelial Cell Proliferation Protein Kinase D Signaling Metanephric Smooth Muscle Tissue Development Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Skeletal Muscle Fiber Adaptation	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Cardiac Muscle Contraction Cardiac Muscle Tissue Morphogenesis Muscle System Process Muscle Tissue Morphogenesis Muscle Organ Development Heart Contraction Muscle Organ Morphogenesis Striated Muscle Tissue Development Myofibril Assembly Skeletal Muscle Thin Filament Assembly Muscle Tissue Development Striated Muscle Contraction Skeletal Myofibril Assembly Actomyosin Structure Organization Muscle Structure Development Striated Muscle Cell Development Muscle Cell Development Cardiac Muscle Tissue Development Actin Filament-based Process Heart Morphogenesis Striated Muscle Cell Differentiation Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Blood Circulation Muscle Cell Differentiation Ventricular Cardiac Muscle Tissue Development Cardiac Ventricle Morphogenesis Organelle Assembly Heart Development Cardiac Ventricle Development Movement Of Cell Or Subcellular Component Actin Cytoskeleton Organization Skeletal Muscle Fiber Adaptation Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Tissue Morphogenesis Cardiac Chamber Development Tissue Development Regulation Of Muscle Contraction Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Muscle Filament Sliding Myosin Filament Assembly Cardiovascular System Development Positive Regulation Of Phospholipid Biosynthetic Process Cardiolipin Acyl-chain Remodeling Long-chain Fatty Acid Import
Tagcloud ?		activin bmp4 cardiomyogenic discovering dish enthusiasm exploiting hesc hipsc homeodomain homogeneity hpscs implement iroquois irx irx4 mlc2a mlc2v myosin offering passaged pluripotent repairing robustly standardization subpopulation technically tnnt2 troponin
Tagcloud (Difference) ?		activin bmp4 cardiomyogenic discovering dish enthusiasm exploiting hesc hipsc homeodomain homogeneity hpscs implement iroquois irx irx4 mlc2a mlc2v myosin offering passaged pluripotent repairing robustly standardization subpopulation technically tnnt2 troponin
Tagcloud (Intersection) ?