TNNI3 and TNNT1

Number of citations of the paper that reports this interaction (PMID 11904166)
2

Data Source:
HPRD (in vitro)

		TNNI3	TNNT1
Gene Name		troponin I type 3 (cardiac)	troponin T type 1 (skeletal, slow)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex Sarcomere	Cytosol Troponin Complex
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding	Tropomyosin Binding Troponin T Binding
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Heart Development Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Skeletal Muscle Contraction Muscle Filament Sliding Slow-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ACTA1 LYST PAPPA PKD2 PKD2L1 PRKCA RCAN3 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	61 interactors: ARMC8 BLOC1S2 BMPR1B C2orf44 CCDC136 CCDC85B CHD3 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HMP19 HSP90AB1 IMMT KAT5 KRT40 LARP1 LDOC1 MARS MORF4L1 NACAD NAGK NFE2L2 NINL OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TPM1 TPM3 TRA2A TRIM63 UBE2D1 VIM ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768
Entrez ID		7137	7138
HPRD ID		11769	01841
Ensembl ID		ENSG00000129991	ENSG00000105048
Uniprot IDs		P19429 Q6FGX2	P13805
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Skeletal Muscle Contraction Musculoskeletal Movement Movement Of Cell Or Subcellular Component Negative Regulation Of ATPase Activity Skeletal Muscle Adaptation Striated Muscle Contraction Actin Filament-based Process Muscle Tissue Development Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Inorganic Substance Detection Of Abiotic Stimulus Ion Homeostasis Response To Mechanical Stimulus Regulation Of ATPase Activity Heart Morphogenesis Response To Abiotic Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Detection Of Mechanical Stimulus Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Endothelial Cell Migration Muscle Organ Development Positive Regulation Of Endothelial Cell Proliferation Cellular Calcium Ion Homeostasis Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Regulation Of Muscle Filament Sliding Speed Positive Regulation Of Dense Core Granule Biogenesis Muscle Tissue Morphogenesis Calcium Ion Homeostasis Striated Muscle Tissue Development Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Response To Metal Ion Myofibril Assembly Positive Regulation Of Epithelial Cell Migration Response To Interleukin-1 Regulation Of Endothelial Cell Proliferation Protein Kinase D Signaling Metanephric Smooth Muscle Tissue Development Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Skeletal Muscle Fiber Adaptation	Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle System Process Regulation Of Metabolic Process Muscle Contraction Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Muscle Contraction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Movement Of Cell Or Subcellular Component Ventricular Cardiac Muscle Tissue Development Regulation Of Cellular Process Cardiac Muscle Tissue Morphogenesis Signal Transduction Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression Cellular Response To Organic Substance Muscle Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Regulation Of RNA Metabolic Process Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Cellular Macromolecule Biosynthetic Process BMP Signaling Pathway Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Signaling Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Striated Muscle Contraction Positive Regulation Of Cellular Biosynthetic Process Cell Communication Cellular Response To Transforming Growth Factor Beta Stimulus RNA Metabolic Process RNA Biosynthetic Process Response To Transforming Growth Factor Beta Cardiac Muscle Tissue Development Primary MiRNA Processing Cellular Response To Stimulus Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Signaling Pathway Response To Stimulus
Tagcloud ?		activin bmp4 cardiomyogenic discovering dish enthusiasm exploiting hesc hipsc homeodomain homogeneity hpscs implement iroquois irx irx4 mlc2a mlc2v myosin offering passaged pluripotent repairing robustly standardization subpopulation technically tnnt2 troponin	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39
Tagcloud (Difference) ?		activin bmp4 cardiomyogenic discovering dish enthusiasm exploiting hesc hipsc homeodomain homogeneity hpscs implement iroquois irx irx4 mlc2a mlc2v myosin offering passaged pluripotent repairing robustly standardization subpopulation technically tnnt2 troponin	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39
Tagcloud (Intersection) ?