HSPB2 and LGALS1

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	LGALS1
Description		heat shock protein family B (small) member 2	galectin 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Extracellular Matrix Extracellular Exosome Galectin Complex
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	RNA Binding Protein Binding Carbohydrate Binding Lactose Binding Laminin Binding Receptor Ligand Activity
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Plasma Cell Differentiation Apoptotic Process Signal Transduction T Cell Costimulation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Myoblast Differentiation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Inflammatory Response Cell-cell Adhesion Negative Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Dendritic Cell Differentiation
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs			Mercaptoethanol Thiodigalactoside 1,4-Dithiothreitol Artenimol OTX-008
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Fat distribution (HIV) ( 21897333)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	17 interacting genes: CD2 CD4 CD7 CD8A CDC42 GEMIN4 HRAS HSPB2 ITGB1 LGALS3BP MUC16 NLGN3 PTEN PTPRC SPN USP4 VPREB1
Entrez ID		3316	3956
HPRD ID		03712	01040
Ensembl ID		ENSG00000170276	ENSG00000100097
Uniprot IDs		A8KAH6 Q16082	A0A384MR27 P09382
PDB IDs		6F2R	1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 2ZKN 3OY8 3OYW 3T2T 3W58 3W59 4Q1P 4Q1R 4Q26 4Q27 4Q2F 4XBL 4Y1U 4Y1V 4Y1X 4Y1Y 4Y1Z 4Y20 4Y22 4Y24 5MWT 5MWX 6B94 6F83 6M5Y 7LTA 7NML 8B0W 8B0Z 8OJP 8R74 8RDC
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	External Side Of Plasma Membrane Lymphocyte Activation T Cell Activation Leukocyte Activation Cell Adhesion Cell Activation Immune System Process T Cell Selection Rhythmic Synaptic Transmission Signaling Receptor Activity Heterotypic Cell-cell Adhesion Positive Regulation Of Cytokine Production Mononuclear Cell Differentiation Positive Regulation Of Cell Population Proliferation Cellular Defense Response Membrane Raft Distribution Cell Surface Membrane Raft Localization Leukocyte Differentiation Coreceptor Activity Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Presynaptic Membrane Assembly Cell Surface Receptor Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Presynaptic Membrane Organization Regulation Of Adaptive Immune Response Protein Kinase Binding Positive Regulation Of Intracellular Signal Transduction Negative Thymic T Cell Selection Positive Regulation Of Signal Transduction Negative T Cell Selection Regulation Of Cytokine Production Cell-cell Adhesion Immune Response Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Lymphocyte Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of T Cell Mediated Immunity Dendritic Spine Morphogenesis Cytoplasmic Side Of Plasma Membrane Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of T Cell Proliferation T Cell Receptor Complex T Cell Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
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