HSPB2 and CRYAB

Number of citations of the paper that reports this interaction (PMID 10625651)
27

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology, pull down, pull down)

		HSPB2	CRYAB
Gene Name		heat shock 27kDa protein 2	crystallin, alpha B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Z Disc Actin Filament Bundle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Enzyme Activator Activity	Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Unfolded Protein Binding
	Biological Process	Response To Unfolded Protein Positive Regulation Of Catalytic Activity	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Homooligomerization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: CLK4 CRYAA CRYAB CRYGC DMPK HNRNPD HSPB3 HSPB8 MAPKAPK5 RPS6KA5 SNCA UBL5	44 interactors: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CS DDX20 DES EPB41 FCGR2A FGF2 GFAP HBA1 HSPB1 HSPB2 HSPB8 INS KRTAP19-5 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PSMA3 SNCA SOD1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		3316	1410
HPRD ID		03712	00428
Ensembl ID			ENSG00000109846
Uniprot IDs		A8KAH6 Q16082	P02511
PDB IDs			2KLR 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS
Enriched GO Terms of Interacting Partners?		Phosphorylation MAPK Cascade Regulation Of Histone Acetylation Signal Transduction By Phosphorylation Aging Histone H2A-S1 Phosphorylation Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Norepinephrine Uptake Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Response To Interleukin-1 Negative Regulation Of Transport Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Intracellular Transport Posttranscriptional Regulation Of Gene Expression Phosphate-containing Compound Metabolic Process Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Negative Regulation Of Dopamine Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Cellular Respiration Negative Regulation Of Intracellular Transport Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Histone Modification Histone H3-S10 Phosphorylation Negative Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Histone Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein Metabolic Process Response To Iron(II) Ion Cellular Response To Copper Ion Circadian Regulation Of Translation Protein Phosphorylation Visual Perception Sensory Perception Of Light Stimulus Regulation Of Synaptic Vesicle Recycling Tubulin Complex Assembly Histone H3-S28 Phosphorylation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Chromosome Organization Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein Phosphorylation	Response To Stress Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To External Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Lipid Metabolic Process Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of Growth Response To Wounding Neuron Apoptotic Process Camera-type Eye Development Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of Neuron Apoptotic Process Regulation Of Lipid Biosynthetic Process Organ Development Neuron Death Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Eye Development Programmed Cell Death Sensory Organ Development Response To Oxidative Stress Platelet Degranulation Sensory Perception
Tagcloud ?		apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic trap1	adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide
Tagcloud (Difference) ?		apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb3 hspb4 hspb7 hspb9 oligodactylic performs phocomelic trap1	adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide
Tagcloud (Intersection) ?		hsps