TNNI3 and TNNC1

Number of citations of the paper that reports this interaction (PMID 16302972)
21

Data Source:
HPRD (in vitro)

		TNNI3	TNNC1
Gene Name		troponin I type 3 (cardiac)	troponin C type 1 (slow)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Troponin Complex Sarcomere	Nucleoplasm Mitochondrion Cytosol Troponin Complex Actin Cytoskeleton
	Molecular Function	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Metal Ion Binding Calcium-dependent Protein Binding	Calcium Ion Binding Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Heart Development Muscle Filament Sliding Negative Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction	Diaphragm Contraction Regulation Of Muscle Contraction Response To Metal Ion Muscle Filament Sliding Regulation Of Muscle Filament Sliding Speed Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs		N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide	Trifluoperazine Levosimendan Felodipine Bepridil Calcium Dihydroxyaluminium 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		14 interactors: ACTA1 LYST PAPPA PKD2 PKD2L1 PRKCA RCAN3 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63	11 interactors: CDK1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TRIM63 UBE2C
Entrez ID		7137	7134
HPRD ID		11769	08930
Ensembl ID		ENSG00000129991	ENSG00000114854
Uniprot IDs		P19429 Q6FGX2	P63316 Q6FH91
PDB IDs		1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R	1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Skeletal Muscle Contraction Musculoskeletal Movement Movement Of Cell Or Subcellular Component Negative Regulation Of ATPase Activity Skeletal Muscle Adaptation Striated Muscle Contraction Actin Filament-based Process Muscle Tissue Development Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Inorganic Substance Detection Of Abiotic Stimulus Ion Homeostasis Response To Mechanical Stimulus Regulation Of ATPase Activity Heart Morphogenesis Response To Abiotic Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Detection Of Mechanical Stimulus Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Endothelial Cell Migration Muscle Organ Development Positive Regulation Of Endothelial Cell Proliferation Cellular Calcium Ion Homeostasis Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Regulation Of Muscle Filament Sliding Speed Positive Regulation Of Dense Core Granule Biogenesis Muscle Tissue Morphogenesis Calcium Ion Homeostasis Striated Muscle Tissue Development Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Response To Metal Ion Myofibril Assembly Positive Regulation Of Epithelial Cell Migration Response To Interleukin-1 Regulation Of Endothelial Cell Proliferation Protein Kinase D Signaling Metanephric Smooth Muscle Tissue Development Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Skeletal Muscle Fiber Adaptation	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Negative Regulation Of ATPase Activity Actin Filament-based Process Striated Muscle Contraction Striated Muscle Tissue Development Muscle Tissue Development Cardiac Ventricle Development Movement Of Cell Or Subcellular Component Cardiac Chamber Development Muscle Structure Development Heart Development Skeletal Muscle Contraction Heart Morphogenesis Regulation Of ATPase Activity Musculoskeletal Movement Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Muscle Organ Development Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Cardiovascular System Development Pronuclear Fusion Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of MRNA Processing Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Free Ubiquitin Chain Polymerization Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Positive Regulation Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination
Tagcloud ?		activin bmp4 cardiomyogenic discovering dish enthusiasm exploiting hesc hipsc homeodomain homogeneity hpscs implement iroquois irx irx4 mlc2a mlc2v myosin offering passaged pluripotent repairing robustly standardization subpopulation technically tnnt2 troponin
Tagcloud (Difference) ?		activin bmp4 cardiomyogenic discovering dish enthusiasm exploiting hesc hipsc homeodomain homogeneity hpscs implement iroquois irx irx4 mlc2a mlc2v myosin offering passaged pluripotent repairing robustly standardization subpopulation technically tnnt2 troponin
Tagcloud (Intersection) ?