HSPB2 and MT-CO1

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	MT-CO1
Description		heat shock protein family B (small) member 2	cytochrome c oxidase subunit I
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	Cytochrome-c Oxidase Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Response To Hypoxia Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Response To Oxidative Stress Aerobic Respiration Cerebellum Development Respiratory Electron Transport Chain Cellular Respiration Response To Copper Ion Response To Electrical Stimulus Proton Transmembrane Transport
Pathways			Mitochondrial translation termination TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Mitochondrial protein degradation Complex IV assembly
Drugs			Cholic Acid N-Formylmethionine Oxygen
Diseases			Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS		Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	11 interacting genes: CDC42 CLEC4G COX4I1 COX5A DLG4 HSPB2 KCNMB1 LIG4 MEOX2 PRDX4 SNCA
Entrez ID		3316	4512
HPRD ID		03712	02469
Ensembl ID		ENSG00000170276	ENSG00000198804
Uniprot IDs		A8KAH6 Q16082	P00395 U5YWV7
PDB IDs		6F2R	5Z62
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	Dendritic Spine Morphogenesis Electron Transport Chain Respiratory Chain Complex IV Respiratory Electron Transport Chain Mitochondrial Electron Transport, Cytochrome C To Oxygen Cytochrome-c Oxidase Activity Response To Metal Ion Oxidative Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Dendritic Spine Organization Cellular Response To Metal Ion Positive Regulation Of Cellular Component Organization Neuron Projection Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Postsynapse Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Postsynapse P2Y1 Nucleotide Receptor Binding Establishment Of Integrated Proviral Latency JUN Phosphorylation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Virus Coreceptor Activity Regulation Of Neuronal Synaptic Plasticity GBD Domain Binding Storage Vacuole Regulation Of Endocytosis Mitochondrial Intermembrane Space Generation Of Precursor Metabolites And Energy Aerobic Electron Transport Chain Chemical Synaptic Transmission Voltage-gated Potassium Channel Complex Enzyme Activator Activity Establishment Of Viral Latency Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Periphery Endothelin Receptor Signaling Pathway Involved In Heart Process Aerobic Respiration Protein Phosphatase Binding Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Trans-synaptic Signaling Synaptic Signaling DNA Ligase (ATP) Activity DNA Ligase IV Complex
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