HSPB2 and SLC2A1

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	SLC2A1
Description		heat shock protein family B (small) member 2	solute carrier family 2 member 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Golgi Membrane Female Germ Cell Nucleus Photoreceptor Inner Segment Female Pronucleus Cytoplasm Cytosol Plasma Membrane Caveola Cell-cell Junction Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc Midbody Cortical Actin Cytoskeleton Vesicle Sarcolemma Melanosome Membrane Raft Synapse Extracellular Exosome Blood Microparticle Presynapse Glucose Transporter Complex
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding Fucose Transmembrane Transporter Activity Kinase Binding Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Response To Hypoxia Central Nervous System Development Female Pregnancy Fucose Transmembrane Transport Long-chain Fatty Acid Import Across Plasma Membrane L-ascorbic Acid Metabolic Process Cerebral Cortex Development Response To Insulin Cellular Response To Glucose Starvation Xenobiotic Transport Photoreceptor Cell Maintenance D-glucose Import Transmembrane Transport Protein-containing Complex Assembly Dehydroascorbic Acid Transport Cellular Response To Mechanical Stimulus Cellular Hyperosmotic Response D-glucose Import Across Plasma Membrane Transport Across Blood-brain Barrier Response To Thyroglobulin Triiodothyronine D-glucose Transmembrane Transport
Pathways			Cellular hexose transport Vitamin C (ascorbate) metabolism Regulation of insulin secretion Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Lactose synthesis
Drugs			Resveratrol Carboxymethylcellulose
Diseases			GLUT1 deficiency syndrome (GLUT1DS); Glucose transport defect of the blood-brain barrier Primary torsion dystonia (PTD)
GWAS		Hip circumference adjusted for BMI ( 34021172)	Birth weight ( 31043758) Cardiac hypertrophy ( 21348951) Immature fraction of reticulocytes ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Pre-treatment viral load in HIV-1 infection ( 31219150) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) White blood cell count ( 32888494)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	18 interacting genes: CALR CANX CCR2 COPS6 GAPDH GIPC1 GPR35 HSPB2 LTB4R2 PDIA3 PTK2B STOM SUMO1 TXNIP UBE2I USP2 VHL WWP1
Entrez ID		3316	6513
HPRD ID		03712	00683
Ensembl ID		ENSG00000170276	ENSG00000117394
Uniprot IDs		A8KAH6 Q16082	P11166 Q59GX2
PDB IDs		6F2R	4PYP 5EQG 5EQH 5EQI 6THA
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	Protein Folding In Endoplasmic Reticulum Perinuclear Region Of Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Protein Stability Small Protein Activating Enzyme Binding Protein Stabilization MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex Negative Regulation Of Catalytic Activity Protein Modification Process Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cell Communication Regulation Of Cell Communication Glutamatergic Synapse Regulation Of Signaling Chemokine-mediated Signaling Pathway Cellular Response To Interleukin-7 Response To Interleukin-7 Post-translational Protein Modification Protein Folding Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Transcription Factor Binding Positive Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Monoatomic Ion Transport Chemokine Receptor Activity Protein Modification By Small Protein Conjugation Endoplasmic Reticulum Quality Control Compartment Negative Regulation Of RNA Biosynthetic Process Regulation Of Lymphocyte Chemotaxis Unfolded Protein Binding Negative Regulation Of Transporter Activity Protein Metabolic Process Presynaptic Cytosol Peptide Binding Postsynaptic Cytosol Lumenal Side Of Endoplasmic Reticulum Membrane Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Potassium Ion Transport Negative Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Signaling Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Synaptic Transmission, Glutamatergic
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?