HSPB2 and PARVA

Number of citations of the paper that reports this interaction (PubMedID 26465331)
76

Data Source:
BioGRID (two hybrid)

		HSPB2	PARVA
Description		heat shock protein family B (small) member 2	parvin alpha
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Z Disc Anchoring Junction
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity Unfolded Protein Binding	Actin Binding Protein Kinase Inhibitor Activity Protein Binding Cadherin Binding
	Biological Process	Response To Unfolded Protein Somatic Muscle Development Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process	Angiogenesis Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Chemotaxis Cell Adhesion Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Organization Actin Cytoskeleton Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Protein Stabilization Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Plasma Membrane Bounded Cell Projection Assembly
Pathways			Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) HOMA-B (corrected for HOMA-IR) ( 30369944) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778) Rheumatic heart disease ( 34106200)
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	15 interacting genes: ACTA1 APP FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 OGT PXN UBE3A UBQLN1
Entrez ID		3316	55742
HPRD ID		03712	16283
Ensembl ID		ENSG00000170276	ENSG00000197702
Uniprot IDs		A8KAH6 Q16082	Q9NVD7
PDB IDs		6F2R	2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB
Enriched GO Terms of Interacting Partners?		Sarcomere Organization Sarcomere M Band Z Disc Striated Muscle Contraction Actomyosin Structure Organization Cardiac Muscle Tissue Morphogenesis Actin-mediated Cell Contraction Muscle Contraction ATP Metabolic Process Cardiac Muscle Contraction Generation Of Precursor Metabolites And Energy Skeletal Muscle Thin Filament Assembly Muscle Tissue Morphogenesis Actin Filament-based Process Actin-myosin Filament Sliding Muscle System Process Actin Filament-based Movement Cytoplasm Actin Cytoskeleton Organization I Band Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Cytoskeleton Organization Extracellular Exosome Actin Cytoskeleton Purine Ribonucleotide Metabolic Process Muscle Filament Sliding Nucleotide Metabolic Process Respiratory Electron Transport Chain Purine Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Electron Transport Chain Cellular Respiration Mitochondrion Monocarboxylic Acid Metabolic Process Cardiac Myofibril Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Nucleoside Phosphate Metabolic Process Glycolytic Process Cardiac Muscle Hypertrophy ADP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process Tertiary Granule Lumen Purine Ribonucleoside Diphosphate Catabolic Process Response To Hypoxia Protein Refolding	Integrin Binding Substrate Adhesion-dependent Cell Spreading Cell-substrate Adhesion Anchoring Junction Focal Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteolysis Cell Cortex Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Biosynthetic Process Glial Cell Development Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Cell-substrate Adhesion Integrin Activation Positive Regulation Of Integrin Activation Positive Regulation Of Gene Expression Cytosol Regulation Of Purine Nucleotide Metabolic Process Regulation Of Cell Adhesion Stress Fiber Chemical Homeostasis Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Response To Endoplasmic Reticulum Stress Cell Development Regulation Of Cell Junction Assembly Regulation Of Protein Localization Regulation Of Integrin Activation Positive Regulation Of Cell Migration Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Cell Motility Schwann Cell Development Regulation Of Cell Migration Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Small Molecule Metabolic Process Protein Serine/threonine Kinase Binding
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