SNX1 and TK1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SNX1	TK1
Description		sorting nexin 1	thymidine kinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Vesicle Protein-containing Complex Cell Projection	Nucleus Cytoplasm Cytosol
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding	Nucleotide Binding Thymidine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Protein Transport Endosomal Transport Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis	Nucleobase-containing Compound Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Thymidine Metabolic Process Thymidine Biosynthetic Process Protein Homotetramerization DNA Biosynthetic Process DNA Synthesis Involved In Mitotic DNA Replication
Pathways			G1/S-Specific Transcription Pyrimidine salvage
Drugs			Dithioerythritol Thymidine 5'-triphosphate
Diseases
GWAS			Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Leukocyte telomere length ( 32109421) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414 32888494)
Interacting Genes		49 interacting genes: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ARMC12 ATXN7 CCDC148 CHRNG CMTM4 CMTM5 COQ3 EGFR F2R FAM25A FAM25C FAM25G FKBP7 FUNDC1 HCCS HGS INSR LEPR LIME1 MPC2 NRIP1 PDGFRB PLIN3 RABAC1 REEP5 REEP6 RHEX RTN3 RTN4 SASH1 SDCBP SDR16C5 SFT2D1 SH3GLB1 SNCA SNX2 SNX6 SYNGR1 SYP TK1 TMEM239 UFD1 VPS35	166 interacting genes: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ATG16L2 ATP5F1B ATP6V1A ATXN3 BAG6 BOLA2 BOLA2B CARHSP1 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CFTR CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 DYNC2I1 DYNLT2B EEF1A1 EIF3G EIF4A2 EIF6 ERG28 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GET3 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K INTS11 ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL20-AS1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PJA1 PKM PLD3 PLXNA3 PPP4C PRMT1 PROC PSME1 PTPN4 PTPRK QARS1 RBBP4 RBM48 REX1BD RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPTIN6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO2 SUMO3 TAF1C THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UBC UNC119 UPF2 USP4 VMA22 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZXDC
Entrez ID		6642	7083
HPRD ID		03171	01771
Ensembl ID		ENSG00000028528	ENSG00000167900
Uniprot IDs		Q13596	A0A384MDV9 K7ERV3 K7ES52 P04183
PDB IDs		2I4K 4FZS 8A1G 8ABQ 8AFZ	1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Formation Cellular Response To Growth Factor Stimulus Receptor Complex Regulation Of Long-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Membrane Organization Response To Growth Factor Positive Regulation Of Locomotion Positive Regulation Of Cell Migration PTB Domain Binding Regulation Of Neuronal Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vesicle-mediated Transport Regulation Of Transport Retromer Complex Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Cell Motility Activin Receptor Activity Cell Migration Involved In Vasculogenesis Retromer, Tubulation Complex Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Lysosome Identical Protein Binding Membrane Organization Positive Regulation Of Transport Positive Regulation Of Activin Receptor Signaling Pathway Cytoplasmic Vesicle Tubular Endosome Activin Receptor Complex Regulation Of Locomotion Establishment Of Protein Localization Synapse Early Endosome Membrane Cadherin Binding Regulation Of Synaptic Plasticity Positive Regulation Of MAPK Cascade Neuron Projection Activin Binding Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Modulation Of Chemical Synaptic Transmission Transmembrane Receptor Protein Serine/threonine Kinase Activity	Cytoplasm Macromolecule Metabolic Process Protein Metabolic Process Platelet Alpha Granule Lumen Chromatin Organization Blood Microparticle Negative Regulation Of Cell Cycle G1/S Phase Transition Chromatin Remodeling Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Extracellular Exosome Cytosol Regulation Of DNA Replication Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Binding Nucleoplasm Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Transferase Activity Nuclear Matrix Regulation Of Protein Catabolic Process DNA Synthesis Involved In Mitotic DNA Replication Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Macromolecule Biosynthetic Process Chromosome, Telomeric Region Positive Regulation Of Protein Metabolic Process Cytoskeleton Negative Regulation Of Cell Cycle Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Protein Tag Activity Developmental Process Growth Cone Protein Modification Process Cellular Response To Norepinephrine Stimulus Response To Norepinephrine Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Oocyte Growth
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