SNX1 and ARL6IP1

Number of citations of the paper that reports this interaction (PubMedID 21516116)
20

Data Source:
BioGRID (two hybrid)

		SNX1	ARL6IP1
Description		sorting nexin 1	ARL6 interacting reticulophagy regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Vesicle Protein-containing Complex Cell Projection	Cytoplasm Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding	Protein Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Protein Transport Endosomal Transport Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis	Positive Regulation Of L-glutamate Import Across Plasma Membrane Cotranslational Protein Targeting To Membrane Apoptotic Process Negative Regulation Of Apoptotic Process Endoplasmic Reticulum Tubular Network Formation Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Membrane Organization
Pathways
Drugs
Diseases
GWAS			Caffeine consumption from coffee or tea ( 33287642) Refractive error ( 32231278)
Interacting Genes		49 interacting genes: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ARMC12 ATXN7 CCDC148 CHRNG CMTM4 CMTM5 COQ3 EGFR F2R FAM25A FAM25C FAM25G FKBP7 FUNDC1 HCCS HGS INSR LEPR LIME1 MPC2 NRIP1 PDGFRB PLIN3 RABAC1 REEP5 REEP6 RHEX RTN3 RTN4 SASH1 SDCBP SDR16C5 SFT2D1 SH3GLB1 SNCA SNX2 SNX6 SYNGR1 SYP TK1 TMEM239 UFD1 VPS35	78 interacting genes: ACSF2 AQP6 ARL4D ARL6 BCL2L13 C19orf18 CERT1 DIABLO DRC4 EHD3 EMP1 F2RL1 FBXW7 FDFT1 FXR2 GAD2 GOLPH3 GOLPH3L GORASP2 GPR151 GPR152 HGS HMGCL HSD17B13 INPP5K LMNA MCEMP1 MGST3 MIEF2 MTERF3 MYG1 NAPB NDRG4 NTAQ1 NUDT3 PAM16 PBX3 PICK1 PTPN9 RAB33A REEP6 RETREG3 RNF5 SDCBP SENP2 SHISA5 SHMT2 SLC10A6 SLC13A1 SLC35H1 SLC61A1 SLC71A2 SNX1 SNX10 SNX11 SNX12 SNX15 SNX2 SNX3 SNX4 SNX8 SPG21 STARD4 SUCLA2 TARS2 TFAM TMED8 TMEM14B TMEM248 TMEM258 TUFM UBE2I VMA21 WDFY2 WIPI2 YIPF4 ZFYVE21 ZNF391
Entrez ID		6642	23204
HPRD ID		03171	09641
Ensembl ID		ENSG00000028528	ENSG00000170540
Uniprot IDs		Q13596	Q15041
PDB IDs		2I4K 4FZS 8A1G 8ABQ 8AFZ
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Formation Cellular Response To Growth Factor Stimulus Receptor Complex Regulation Of Long-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Membrane Organization Response To Growth Factor Positive Regulation Of Locomotion Positive Regulation Of Cell Migration PTB Domain Binding Regulation Of Neuronal Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vesicle-mediated Transport Regulation Of Transport Retromer Complex Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Cell Motility Activin Receptor Activity Cell Migration Involved In Vasculogenesis Retromer, Tubulation Complex Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Lysosome Identical Protein Binding Membrane Organization Positive Regulation Of Transport Positive Regulation Of Activin Receptor Signaling Pathway Cytoplasmic Vesicle Tubular Endosome Activin Receptor Complex Regulation Of Locomotion Establishment Of Protein Localization Synapse Early Endosome Membrane Cadherin Binding Regulation Of Synaptic Plasticity Positive Regulation Of MAPK Cascade Neuron Projection Activin Binding Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Modulation Of Chemical Synaptic Transmission Transmembrane Receptor Protein Serine/threonine Kinase Activity	Lipid Binding Phosphatidylinositol Binding Cellular Localization Establishment Of Protein Localization Retromer Complex Intracellular Transport Protein Transport Membrane Establishment Of Localization In Cell Leptin Receptor Binding Localization Within Membrane Intracellular Protein Transport Early Endosome To Golgi Transport Intracellular Protein Localization Vesicle-mediated Transport To The Plasma Membrane Golgi Vesicle Transport Retrograde Transport, Endosome To Golgi Endosome Phosphatidylinositol-4-phosphate Binding Transferrin Receptor Binding Negative Regulation Of Early Endosome To Late Endosome Transport Endosomal Transport Endocytic Recycling Cytosolic Transport Early Endosome Membrane Phosphatidylinositol-3-phosphate Binding Protein Targeting To Golgi Apparatus Protein Binding Mitochondrial Matrix Early Endosome Retromer, Tubulation Complex Golgi Vesicle Budding Cargo Adaptor Activity Establishment Of Protein Localization To Plasma Membrane Insulin Receptor Binding Vesicle-mediated Transport Organelle Organization Phosphatidylinositol Phosphate Binding Late Endosome To Golgi Transport Succinate Metabolic Process Lamellipodium Morphogenesis Epidermal Growth Factor Receptor Binding Vesicle Budding From Membrane Protein Localization To Membrane Vesicle Organization Positive Regulation Of Exocytosis Regulation Of Establishment Of Protein Localization Membrane Organization Golgi Cisterna Regulation Of Protein Localization
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