SNX1 and ATXN7

Number of citations of the paper that reports this interaction (PMID 21078624)
14

Data Source:
BioGRID (two hybrid)

		SNX1	ATXN7
Gene Name		sorting nexin 1	ataxin 7
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Endosome Membrane Membrane Extrinsic Component Of Membrane Lamellipodium Retromer Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Protein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Transferrin Receptor Binding Leptin Receptor Binding	Chromatin Binding Protein Binding
	Biological Process	Intracellular Protein Transport Vesicle Organization Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis	Microtubule Cytoskeleton Organization Chromatin Organization Transcription, DNA-templated Nucleus Organization Visual Perception Histone Deubiquitination Negative Regulation Of Phosphorylation Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ATXN7 CMTM5 EGFR F2R FUNDC1 HGS INSR LEPR PDGFRB RABAC1 REEP6 RTN3 RTN4 SNX2 SNX32 SNX6 TK1 UFD1L VPS35	59 interactors: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN HIST1H3A JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SSFA2 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 VCP VWF
Entrez ID		6642	6314
HPRD ID		03171	06365
Ensembl ID		ENSG00000028528	ENSG00000163635
Uniprot IDs		Q13596	O15265 Q9UPD8
PDB IDs		2I4K 4FZS	2KKR
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive System Development Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Activin Receptor Signaling Pathway Endoplasmic Reticulum Tubular Network Organization Regulation Of Signal Transduction Regulation Of Cell Motility Retrograde Transport, Endosome To Golgi Protein Transport Regulation Of Locomotion Regulation Of Cellular Component Movement Endosomal Transport Regulation Of Peptidyl-tyrosine Phosphorylation Vesicle Organization Protein Localization Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Kinase Activity Regulation Of JAK-STAT Cascade Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction By Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Cycle Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Intracellular Protein Transport Positive Regulation Of Mitotic Cell Cycle	Extracellular Matrix Organization Extracellular Structure Organization Response To Stimulus Cell-substrate Junction Assembly Cell-substrate Adhesion Platelet Degranulation Cellular Localization Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Vesicle-mediated Transport Regulation Of Protein Metabolic Process Establishment Of Localization In Cell Cell Junction Assembly Protein Localization To Tight Junction Regulation Of Metabolic Process Histone Deubiquitination Regulation Of Cellular Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Response To Wounding Regulation Of Protein Catabolic Process Regulation Of Cell Death Protein Ubiquitination Protein Polyubiquitination Blood Coagulation Cellular Protein Modification Process Hemostasis Positive Regulation Of Proteolysis Focal Adhesion Assembly Cellular Component Assembly Protein Localization Extracellular Matrix Disassembly Platelet Activation Regulation Of Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Protein Complex Assembly Regulation Of Signaling Cellular Protein Metabolic Process Protein Localization To Cell Junction Cell Death Death Response To Stress Nervous System Development Positive Regulation Of Protein Catabolic Process Secretion By Cell Substrate Adhesion-dependent Cell Spreading Adherens Junction Assembly Protein Metabolic Process
Tagcloud ?		apical auxin brassinosteroid bundle carrier clasp cytokinin cytoskeleton division edges efflux elongation endosomes fine maxima meristem microtubule microtubules modulates normally optimize pin2 prevailing sharp tethering transfacial transitions tunes works	accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Difference) ?		apical auxin brassinosteroid bundle carrier clasp cytokinin cytoskeleton division edges efflux elongation endosomes fine maxima meristem microtubule microtubules modulates normally optimize pin2 prevailing sharp tethering transfacial transitions tunes works	accounts asian ataxia ataxias atn1 atxn1 atxn2 atxn3 cag caucasians causal causative consortium ethnic expanded expansions explained geographical htt influenced modifier polyglutamine quadratic reflected replicated sister spinocerebellar tbp variability
Tagcloud (Intersection) ?