SNX1 and CHRNG

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNX1	CHRNG
Description		sorting nexin 1	cholinergic receptor nicotinic gamma subunit
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Vesicle Protein-containing Complex Cell Projection	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Neuron Projection Synapse Postsynaptic Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Intracellular Protein Transport Protein Transport Endosomal Transport Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis	Skeletal Muscle Contraction Monoatomic Ion Transport Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Monoatomic Ion Transmembrane Transport Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway
Pathways			Highly sodium permeable postsynaptic acetylcholine nicotinic receptors
Drugs
Diseases			Multiple pterygium syndrome, including: Multiple pterygium syndrome, lethal type (LMPS); Multiple pterygium syndrome, Escobar variant (EVMPS)
GWAS			Refractive error ( 23396134 32231278)
Interacting Genes		49 interacting genes: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ARMC12 ATXN7 CCDC148 CHRNG CMTM4 CMTM5 COQ3 EGFR F2R FAM25A FAM25C FAM25G FKBP7 FUNDC1 HCCS HGS INSR LEPR LIME1 MPC2 NRIP1 PDGFRB PLIN3 RABAC1 REEP5 REEP6 RHEX RTN3 RTN4 SASH1 SDCBP SDR16C5 SFT2D1 SH3GLB1 SNCA SNX2 SNX6 SYNGR1 SYP TK1 TMEM239 UFD1 VPS35	21 interacting genes: ADAMTSL4 CHRNA1 CYSRT1 KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP5-9 KRTAP9-3 MDFI MEOX2 NBPF19 NOTCH2NLA SGTA SNX1 SPRY2
Entrez ID		6642	1146
HPRD ID		03171	00009
Ensembl ID		ENSG00000028528	ENSG00000196811
Uniprot IDs		Q13596	A0A6F7YAP6 P07510
PDB IDs		2I4K 4FZS 8A1G 8ABQ 8AFZ
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Formation Cellular Response To Growth Factor Stimulus Receptor Complex Regulation Of Long-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Membrane Organization Response To Growth Factor Positive Regulation Of Locomotion Positive Regulation Of Cell Migration PTB Domain Binding Regulation Of Neuronal Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Vesicle-mediated Transport Regulation Of Transport Retromer Complex Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Positive Regulation Of Cell Motility Activin Receptor Activity Cell Migration Involved In Vasculogenesis Retromer, Tubulation Complex Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Lysosome Identical Protein Binding Membrane Organization Positive Regulation Of Transport Positive Regulation Of Activin Receptor Signaling Pathway Cytoplasmic Vesicle Tubular Endosome Activin Receptor Complex Regulation Of Locomotion Establishment Of Protein Localization Synapse Early Endosome Membrane Cadherin Binding Regulation Of Synaptic Plasticity Positive Regulation Of MAPK Cascade Neuron Projection Activin Binding Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Calcium Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Modulation Of Chemical Synaptic Transmission Transmembrane Receptor Protein Serine/threonine Kinase Activity	Keratin Filament Intermediate Filament Identical Protein Binding Epidermis Development Structural Constituent Of Skin Epidermis
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