SNX1 and F2R

Number of citations of the paper that reports this interaction (PMID 12058063)
24

Data Source:
HPRD (in vivo, in vitro)

		SNX1	F2R
Gene Name		sorting nexin 1	coagulation factor II (thrombin) receptor
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Endosome Membrane Membrane Extrinsic Component Of Membrane Lamellipodium Retromer Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Protein Complex	Extracellular Region Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Transferrin Receptor Binding Leptin Receptor Binding	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Receptor Binding Protein Binding Thrombin Receptor Activity G-protein Beta-subunit Binding
	Biological Process	Intracellular Protein Transport Vesicle Organization Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis	Activation Of MAPKK Activity Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Tyrosine Phosphorylation Of STAT Protein STAT Protein Import Into Nucleus Establishment Of Synaptic Specificity At Neuromuscular Junction Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of JAK-STAT Cascade Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Platelet Dense Granule Organization Positive Regulation Of ERK1 And ERK2 Cascade Thrombin Receptor Signaling Pathway Negative Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) Common Pathway G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation
Drugs			Streptokinase
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		25 interactors: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ATXN7 CMTM5 EGFR F2R FUNDC1 HGS INSR LEPR PDGFRB RABAC1 REEP6 RTN3 RTN4 SNX2 SNX32 SNX6 TK1 UFD1L VPS35	17 interactors: ATP13A2 CAPN1 CHRD CTSG ELANE F2 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNX1
Entrez ID		6642	2149
HPRD ID		03171	01763
Ensembl ID		ENSG00000028528	ENSG00000181104
Uniprot IDs		Q13596	P25116 Q2TNB2
PDB IDs		2I4K 4FZS	1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive System Development Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Activin Receptor Signaling Pathway Endoplasmic Reticulum Tubular Network Organization Regulation Of Signal Transduction Regulation Of Cell Motility Retrograde Transport, Endosome To Golgi Protein Transport Regulation Of Locomotion Regulation Of Cellular Component Movement Endosomal Transport Regulation Of Peptidyl-tyrosine Phosphorylation Vesicle Organization Protein Localization Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Kinase Activity Regulation Of JAK-STAT Cascade Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction By Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Cycle Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Intracellular Protein Transport Positive Regulation Of Mitotic Cell Cycle	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Platelet Activation Response To Wounding Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Extracellular Matrix Disassembly Positive Regulation Of Cell Proliferation Regulation Of Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Killing By Host Of Symbiont Cells Leukocyte Migration Receptor Metabolic Process Negative Regulation Of Fibrinolysis Response To Stress Receptor Catabolic Process Regulation Of Fibrinolysis Proteolysis G-protein Coupled Acetylcholine Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Locomotion Cellular Homeostasis Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Cellular Metal Ion Homeostasis Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Regulation Of Cell Shape Fibrinolysis Cellular Cation Homeostasis Positive Regulation Of Blood Coagulation Cellular Ion Homeostasis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Interaction With Symbiont Leukocyte Mediated Cytotoxicity Cytosolic Calcium Ion Homeostasis Metal Ion Homeostasis Regulation Of Signal Transduction Positive Regulation Of Coagulation Response To Fungus Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Response To Stimulus Positive Regulation Of Wound Healing Ion Homeostasis
Tagcloud ?		apical auxin brassinosteroid bundle carrier clasp cytokinin cytoskeleton division edges efflux elongation endosomes fine maxima meristem microtubule microtubules modulates normally optimize pin2 prevailing sharp tethering transfacial transitions tunes works	agt card4 casp1 csf2 csf3 curcuma icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia ppm1a raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10
Tagcloud (Difference) ?		apical auxin brassinosteroid bundle carrier clasp cytokinin cytoskeleton division edges efflux elongation endosomes fine maxima meristem microtubule microtubules modulates normally optimize pin2 prevailing sharp tethering transfacial transitions tunes works	agt card4 casp1 csf2 csf3 curcuma icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia ppm1a raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10
Tagcloud (Intersection) ?