TIAL1 and SMN1

Number of citations of the paper that reports this interaction (PMID 15304326)
37

Data Source:
HPRD (in vivo)

		TIAL1	SMN1
Gene Name		TIA1 cytotoxic granule-associated RNA binding protein-like 1	survival of motor neuron 1, telomeric
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytoplasmic Stress Granule Extracellular Vesicular Exosome	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies
	Molecular Function	Nucleotide Binding RNA Binding AU-rich Element Binding Poly(A) RNA Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Defense Response Germ Cell Development Positive Regulation Of Cell Proliferation Stem Cell Division	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process
Pathways			snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MAPK1 SMN1 SMN2	136 interactors: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 APLP1 ARFGAP1 ATP5B ATP6V1A BAG6 BCL2 C19orf60 CARHSP1 CCDC90B CENPB COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EIF3G EXT2 EZH2 FAM20C FBL FGB FLAD1 FUBP1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 HADHB HIST3H3 HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NGFR NKIRAS2 NMT2 OSTF1 PDE4DIP PKM PLXNA3 POLR2A POP7 PSME1 QARS RBBP4 RBBP6 RBFOX2 RBM48 RN7SL1 RNU1-1 RNU2-1 RPL13 RPS2 RXRA SDF4 SEMA5B SETDB1 SMC5 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNUPN SP110 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 WDR18 WDR73 WDYHV1 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC
Entrez ID		7073	6606
HPRD ID		04563	02646
Ensembl ID			ENSG00000172062
Uniprot IDs		Q01085 Q49AS9	B4DP61 Q16637
PDB IDs		1X4G 2CQI 2DH7	1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly Ribonucleoprotein Complex Assembly MAPK Import Into Nucleus MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Golgi Inheritance Ribonucleoprotein Complex Biogenesis Caveolin-mediated Endocytosis Cytosine Metabolic Process RNA Splicing Regulation Of Golgi Organization Nervous System Development MRNA Processing Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus NcRNA Metabolic Process Regulation Of Early Endosome To Late Endosome Transport MRNA Metabolic Process RNA Processing Positive Regulation Of Peptidyl-threonine Phosphorylation Cellular Macromolecular Complex Assembly ERK1 And ERK2 Cascade RNA Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Proliferation Growth Hormone Receptor Signaling Pathway Gene Expression Cellular Response To Growth Hormone Stimulus Labyrinthine Layer Blood Vessel Development Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Pyrimidine Nucleobase Metabolic Process Placenta Blood Vessel Development Lipopolysaccharide-mediated Signaling Pathway B Cell Receptor Signaling Pathway Response To Growth Hormone System Development Peptidyl-threonine Phosphorylation Response To Exogenous DsRNA Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Labyrinthine Layer Development Nucleobase-containing Compound Metabolic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Heat	MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Metabolic Process Spliceosomal SnRNP Assembly Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Macromolecular Complex Assembly Histone MRNA Metabolic Process Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Process Nuclear-transcribed MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Component Assembly MRNA Catabolic Process RNA Catabolic Process CRD-mediated MRNA Stabilization Regulation Of Protein Metabolic Process Termination Of RNA Polymerase II Transcription Regulation Of Cellular Protein Metabolic Process DNA-templated Transcription, Termination RNA Biosynthetic Process MRNA 3'-end Processing Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Transcription, DNA-templated RNA 3'-end Processing Regulation Of Mitotic Cell Cycle Phase Transition Spliceosomal Complex Assembly Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Phase Transition Developmental Process Regulation Of Metabolic Process Cellular Macromolecule Catabolic Process Cell Differentiation Catabolic Process
Tagcloud ?		atxn2 bid ccnf cdkn1a cntn4 dcp1b dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia1 tprkb translocate upregulations wdfy1	atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness
Tagcloud (Difference) ?		atxn2 bid ccnf cdkn1a cntn4 dcp1b dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia1 tprkb translocate upregulations wdfy1	atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn2 splice unusually weakness
Tagcloud (Intersection) ?