TIAL1 and SMN2

Number of citations of the paper that reports this interaction (PMID 15304326)
37

Data Source:
HPRD (in vivo)

		TIAL1	SMN2
Gene Name		TIA1 cytotoxic granule-associated RNA binding protein-like 1	survival of motor neuron 2, centromeric
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Cytoplasmic Stress Granule Extracellular Vesicular Exosome	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cajal Body Z Disc SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies
	Molecular Function	Nucleotide Binding RNA Binding AU-rich Element Binding Poly(A) RNA Binding	RNA Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Defense Response Germ Cell Development Positive Regulation Of Cell Proliferation Stem Cell Division	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly Nervous System Development Gene Expression NcRNA Metabolic Process
Pathways			snRNP Assembly Metabolism of non-coding RNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MAPK1 SMN1 SMN2	24 interactors: BLOC1S6 BYSL CHTOP DDX20 DHX9 FAM9B FBL GAR1 GEMIN2 HNRNPUL1 POLR1C POLR2A PPIG SMN1 SNRPB SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG TIAL1 VPS28
Entrez ID		7073	6607
HPRD ID		04563	09036
Ensembl ID			ENSG00000205571
Uniprot IDs		Q01085 Q49AS9	B4DP61 Q16637
PDB IDs		1X4G 2CQI 2DH7	1G5V 1MHN 2LEH 3S6N 4A4E 4A4G 4GLI
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly Ribonucleoprotein Complex Assembly MAPK Import Into Nucleus MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Golgi Inheritance Ribonucleoprotein Complex Biogenesis Caveolin-mediated Endocytosis Cytosine Metabolic Process RNA Splicing Regulation Of Golgi Organization Nervous System Development MRNA Processing Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus NcRNA Metabolic Process Regulation Of Early Endosome To Late Endosome Transport MRNA Metabolic Process RNA Processing Positive Regulation Of Peptidyl-threonine Phosphorylation Cellular Macromolecular Complex Assembly ERK1 And ERK2 Cascade RNA Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Mammary Gland Epithelial Cell Proliferation Growth Hormone Receptor Signaling Pathway Gene Expression Cellular Response To Growth Hormone Stimulus Labyrinthine Layer Blood Vessel Development Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Pyrimidine Nucleobase Metabolic Process Placenta Blood Vessel Development Lipopolysaccharide-mediated Signaling Pathway B Cell Receptor Signaling Pathway Response To Growth Hormone System Development Peptidyl-threonine Phosphorylation Response To Exogenous DsRNA Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Labyrinthine Layer Development Nucleobase-containing Compound Metabolic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Heat	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly RNA Splicing RNA Processing MRNA Processing Ribonucleoprotein Complex Biogenesis NcRNA Metabolic Process MRNA Metabolic Process Ribonucleoprotein Complex Assembly RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Spliceosomal Complex Assembly Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Termination Cellular Macromolecular Complex Assembly Nitrogen Compound Metabolic Process Termination Of RNA Polymerase II Transcription MRNA 3'-end Processing RNA 3'-end Processing Cellular Metabolic Process Cellular Component Assembly Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RRNA Processing RRNA Metabolic Process Metabolic Process Ribosome Biogenesis Histone Glutamine Methylation Cellular Process Transcription, RNA-templated Peptidyl-glutamine Methylation Positive Regulation Of Type I Interferon Production Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway DNA-templated Transcription, Elongation SnoRNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process CRD-mediated MRNA Stabilization Regulation Of Type I Interferon Production Endosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Helicase Activity Secretion Of Lysosomal Enzymes Late Endosome To Vacuole Transport Osteoblast Differentiation
Tagcloud ?		atxn2 bid ccnf cdkn1a cntn4 dcp1b dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia1 tprkb translocate upregulations wdfy1	atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn1 splice unusually weakness
Tagcloud (Difference) ?		atxn2 bid ccnf cdkn1a cntn4 dcp1b dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia1 tprkb translocate upregulations wdfy1	atrophy centromeric compensate copies copy degeneration deletions detectable display donor easily exon fails fatal harbor hindering homozygous infant intragenic italian modifier muscular null predictable sma smn1 splice unusually weakness
Tagcloud (Intersection) ?