TIAL1 and MIR9-2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		TIAL1	MIR9-2
Description		TIA1 cytotoxic granule associated RNA binding protein like 1	microRNA 9-2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Stress Granule Cytolytic Granule	RISC Complex
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Protein-RNA Adaptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Defense Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Positive Regulation Of MiRNA-mediated Gene Silencing	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		FGFR2 alternative splicing
Drugs
Diseases
GWAS		Depressive symptoms (stressful life events interaction) ( 27529621) Monocyte percentage of white cells ( 32888494) Parkinson's disease ( 27182965) Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) ( 27047539)	Body mass index ( 26426971) Regular attendance at a religious group ( 29970889)
Interacting Genes		42 interacting genes: AKAP8L AOC1 BPIFA1 C10orf55 CAMK2A CEBPA CELF4 CREBBP DAZAP2 FAM168A FAM168B FUBP1 GRINA INCA1 KLF1 KRT31 KRTAP8-1 MAGED1 MAPK1 MAPK1IP1L MBNL2 MIR106A MIR106B MIR145 MIR199A1 MIR20A MIR29A MIR29C MIR34A MIR9-2 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RBPMS2 SMN1 SMN2 SNRPA VPS37C	76 interacting genes: ADARB1 APOBEC3B C1QBP CELF1 CELF2 CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FUS GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NONO NUDT21 PDCD11 PLOD1 PRMT1 PTBP1 PURA PURB QARS1 RARS1 RBFOX2 RBM14 RBM4 RBM4B RBMS2 RTCA RTCB SF3B1 SF3B2 SF3B3 SFPQ SYNCRIP TAF15 TENT2 TIAL1 TRA2A TRA2B UTP20 YBX1 YBX3 ZC3H11A ZFR ZNF346 ZNF385A
Entrez ID		7073	407047
HPRD ID		04563
Ensembl ID		ENSG00000151923	ENSG00000284447
Uniprot IDs		Q01085 Q49AS9
PDB IDs		1X4G 2CQI 2DH7
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing MRNA 3'-UTR Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Regulation Of Cardiac Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Extracellular Vesicle Post-transcriptional Regulation Of Gene Expression Regulation Of Angiogenesis Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Striated Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Positive Regulation Of Tissue Remodeling Negative Regulation Of Circulating Fibrinogen Levels Negative Regulation Of BMP Signaling Pathway RNA Splicing Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Processing Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction MRNA Destabilization Regulation Of MRNA Stability RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing MRNA Processing RNA Metabolic Process RNA Splicing MRNA Binding MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Post-transcriptional Regulation Of Gene Expression Ribonucleoprotein Complex Nucleus MRNA 3'-UTR Binding Nucleoplasm Regulation Of Translation MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of Gene Expression Negative Regulation Of Translation Catalytic Step 2 Spliceosome Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Negative Regulation Of RNA Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Negative Regulation Of Macromolecule Metabolic Process MiRNA Binding Nucleolus Regulation Of RNA Metabolic Process MRNA Stabilization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Protein Metabolic Process Pre-mRNA Binding Positive Regulation Of Cytoplasmic Translation
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