TIAL1 and PRR13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIAL1	PRR13
Description		TIA1 cytotoxic granule associated RNA binding protein like 1	proline rich 13
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Stress Granule Cytolytic Granule	Nucleus Nucleoplasm Cytosol
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Protein-RNA Adaptor Activity	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Defense Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways		FGFR2 alternative splicing
Drugs
Diseases
GWAS		Depressive symptoms (stressful life events interaction) ( 27529621) Monocyte percentage of white cells ( 32888494) Parkinson's disease ( 27182965) Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) ( 27047539)	Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252)
Interacting Genes		42 interacting genes: AKAP8L AOC1 BPIFA1 C10orf55 CAMK2A CEBPA CELF4 CREBBP DAZAP2 FAM168A FAM168B FUBP1 GRINA INCA1 KLF1 KRT31 KRTAP8-1 MAGED1 MAPK1 MAPK1IP1L MBNL2 MIR106A MIR106B MIR145 MIR199A1 MIR20A MIR29A MIR29C MIR34A MIR9-2 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RBPMS2 SMN1 SMN2 SNRPA VPS37C	53 interacting genes: AP2M1 BAIAP2 CBLL2 CELF5 DAZAP2 DVL3 EWSR1 FAM133A FUBP1 FXR1 GPAA1 H2BC15 IL16 KHDC4 KLHL12 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP13-1 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP4-12 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LGALS3 LNX1 MSX2 NKX1-2 OTX1 PEX5 PLSCR1 PPIA PSMA3 PSME3 RBM47 RP9P RTN4 SDCBP SDCBP2 SMUG1 SREK1IP1 SRI TIAL1 TNFAIP8 TRIP13 VAC14 YPEL3 ZCCHC10
Entrez ID		7073	54458
HPRD ID		04563	13211
Ensembl ID		ENSG00000151923	ENSG00000205352
Uniprot IDs		Q01085 Q49AS9	Q9NZ81
PDB IDs		1X4G 2CQI 2DH7
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing MRNA 3'-UTR Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Regulation Of Cardiac Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Extracellular Vesicle Post-transcriptional Regulation Of Gene Expression Regulation Of Angiogenesis Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Striated Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Positive Regulation Of Tissue Remodeling Negative Regulation Of Circulating Fibrinogen Levels Negative Regulation Of BMP Signaling Pathway RNA Splicing Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Processing Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction MRNA Destabilization Regulation Of MRNA Stability RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration	Intermediate Filament Cytosol Keratin Filament Identical Protein Binding
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