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TIAL1
Description
TIA1 cytotoxic granule associated RNA binding protein like 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Lysosome
Cytosol
Cytoplasmic Stress Granule
Cytolytic Granule
Molecular Function
Nucleic Acid Binding
DNA Binding
RNA Binding
MRNA 3'-UTR Binding
Protein Binding
Protein-RNA Adaptor Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Defense Response
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Hippo Signaling
Regulation Of Cell Population Proliferation
Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways
FGFR2 alternative splicing
Drugs
Diseases
GWAS
Depressive symptoms (stressful life events interaction) (
27529621
)
Monocyte percentage of white cells (
32888494
)
Parkinson's disease (
27182965
)
Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) (
27047539
)
Interacting Genes
42 interacting genes:
AKAP8L
AOC1
BPIFA1
C10orf55
CAMK2A
CEBPA
CELF4
CREBBP
DAZAP2
FAM168A
FAM168B
FUBP1
GRINA
INCA1
KLF1
KRT31
KRTAP8-1
MAGED1
MAPK1
MAPK1IP1L
MBNL2
MIR106A
MIR106B
MIR145
MIR199A1
MIR20A
MIR29A
MIR29C
MIR34A
MIR9-2
PRR13
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
QKI
RBPMS2
SMN1
SMN2
SNRPA
VPS37C
Entrez ID
7073
HPRD ID
04563
Ensembl ID
ENSG00000151923
Uniprot IDs
Q01085
Q49AS9
PDB IDs
1X4G
2CQI
2DH7
Enriched GO Terms of Interacting Partners
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MRNA Base-pairing Post-transcriptional Repressor Activity
MiRNA-mediated Post-transcriptional Gene Silencing
MRNA 3'-UTR Binding
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Gene Silencing
Regulation Of Cardiac Muscle Cell Apoptotic Process
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Translation
Negative Regulation Of Vascular Endothelial Growth Factor Production
Negative Regulation Of Vasculature Development
Negative Regulation Of Angiogenesis
Extracellular Vesicle
Post-transcriptional Regulation Of Gene Expression
Regulation Of Angiogenesis
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Vasculature Development
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Developmental Process
Negative Regulation Of Striated Muscle Cell Apoptotic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Regulation Of Vascular Endothelial Growth Factor Production
Regulation Of Translation
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Muscle Cell Apoptotic Process
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of MRNA Metabolic Process
Negative Regulation Of Cytokine Production
Positive Regulation Of Tissue Remodeling
Negative Regulation Of Circulating Fibrinogen Levels
Negative Regulation Of BMP Signaling Pathway
RNA Splicing
Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Gene Expression
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
MRNA Processing
Regulation Of Vascular Endothelial Cell Proliferation
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
MRNA Destabilization
Regulation Of MRNA Stability
RNA Destabilization
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Migration
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