TIAL1 and QKI

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TIAL1	QKI
Description		TIA1 cytotoxic granule associated RNA binding protein like 1	QKI, KH domain containing RNA binding
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Stress Granule Cytolytic Granule	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Synapse
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Protein-RNA Adaptor Activity	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding SH3 Domain Binding MiRNA Binding Internal N(7)-methylguanine-containing RNA Reader Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Defense Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Positive Regulation Of MiRNA-mediated Gene Silencing	Vasculogenesis MRNA Processing Regulation Of Translation Spermatid Development Intracellular MRNA Localization Axon Ensheathment RNA Splicing Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Microglia Differentiation Negative Regulation Of Angiogenesis Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Myelination Negative Regulation Of Type I Interferon Production Stress Granule Assembly Vascular Associated Smooth Muscle Cell Differentiation Myelination Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Macrophage Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Regulation Of Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation MRNA Transport Regulation Of Cell Development Negative Regulation Of Cold-induced Thermogenesis Spliceosome-depend Formation Of Circular RNA Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Myofibroblast Contraction Regulation Of Multicellular Organismal Development Negative Regulation Of MiRNA Catabolic Process
Pathways		FGFR2 alternative splicing	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Depressive symptoms (stressful life events interaction) ( 27529621) Monocyte percentage of white cells ( 32888494) Parkinson's disease ( 27182965) Response to carboplatin and paclitaxel in ovarian cancer (MTT IC50) ( 27047539)	Cataracts ( 34127677) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Fasting insulin ( 34059833) Height ( 31562340) Hemoglobin ( 32888494) Incident myocardial infarction ( 26950853) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Platelet distribution width ( 32888494) Red blood cell count ( 29403010) Refractive error ( 32231278) Response to TNF antagonist treatment ( 18615156) Seasonality and depression ( 30217971) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969 30718926)
Interacting Genes		42 interacting genes: AKAP8L AOC1 BPIFA1 C10orf55 CAMK2A CEBPA CELF4 CREBBP DAZAP2 FAM168A FAM168B FUBP1 GRINA INCA1 KLF1 KRT31 KRTAP8-1 MAGED1 MAPK1 MAPK1IP1L MBNL2 MIR106A MIR106B MIR145 MIR199A1 MIR20A MIR29A MIR29C MIR34A MIR9-2 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RBPMS2 SMN1 SMN2 SNRPA VPS37C	90 interacting genes: ALG13 ANKHD1 APP ATXN1 BAG4 BCAS2 CALD1 CARM1 CCDC59 CCND3 CDKN2D CEBPA CPSF7 DAZ1 DAZ4 DEPP1 DMRTB1 EIF4ENIF1 FBXO7 FHL3 FUBP3 HCLS1 HLCS HNRNPH2 HNRNPK HNRNPLL IL7R KIF21B LSM3 LSM5 MBNL1 MBNL2 MIR141 MIR19B2 MIR200A MIR34B MIR34C MIR7-1 MRPL44 MSI2 NABP1 NEIL3 NIP7 NXF1 PCBP1 PCBP2 PCBP3 PCBP4 PCGF5 PIAS1 PRKAB2 PRMT1 PRPF39 PRPF6 PRRC2B PSMF1 PTBP1 PTBP2 RALY RBFOX1 RBFOX2 RBM11 RBM14 RBM23 RBM42 RBM7 RBPMS RNF138 RPL9 SECISBP2 SERF2 SLAIN1 SNRPA SNRPC TEX11 THAP1 TIAL1 TNRC6A TRNAU1AP TSG101 TXNL4A U2AF2 UNKL USH1C UTP6 WDR77 YTHDF1 YTHDF3 ZC3H10 ZMAT5
Entrez ID		7073	9444
HPRD ID		04563	06691
Ensembl ID		ENSG00000151923	ENSG00000112531
Uniprot IDs		Q01085 Q49AS9	Q8WY44 Q96PU8
PDB IDs		1X4G 2CQI 2DH7	4JVH
Enriched GO Terms of Interacting Partners?		MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing MRNA 3'-UTR Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing Regulation Of Cardiac Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Translation Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Extracellular Vesicle Post-transcriptional Regulation Of Gene Expression Regulation Of Angiogenesis Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Vasculature Development Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Striated Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Positive Regulation Of Tissue Remodeling Negative Regulation Of Circulating Fibrinogen Levels Negative Regulation Of BMP Signaling Pathway RNA Splicing Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Processing Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction MRNA Destabilization Regulation Of MRNA Stability RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration	RNA Binding Nucleic Acid Binding Regulation Of RNA Splicing MRNA Binding RNA Splicing Regulation Of MRNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Processing RNA Metabolic Process Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleoplasm Negative Regulation Of RNA Splicing Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process MRNA 3'-UTR Binding Cytoplasmic Stress Granule Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Commitment Complex Regulation Of Translation Viral RNA Genome Replication Regulation Of MRNA Stability Negative Regulation Of RNA Metabolic Process
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