BYSL and CDC23

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		BYSL	CDC23
Gene Name		bystin-like	cell division cycle 23
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell	Intracellular Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Protein Binding Poly(A) RNA Binding	Ubiquitin-protein Transferase Activity
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Trophectodermal Cell Differentiation Cell Adhesion Female Pregnancy Cell Proliferation	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Mitotic Metaphase Plate Congression Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Regulation Of Exit From Mitosis Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K11-linked Ubiquitination
Pathways			Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Hematological parameters ( 19820697) Mean corpuscular hemoglobin ( 20139978 19862010) Mean corpuscular volume ( 23263863 20139978 19862010) Red blood cell count ( 20139978)
Protein-Protein Interactions		65 interactors: AES AIMP2 APP BEND7 C1orf94 CCDC102B CCDC136 CCDC33 CDC23 CDCA7L CEP44 CEP57L1 CEP70 COIL DDX17 DOCK8 EMD EPS8 FAM9B FXR2 GMCL1 GOLGA2 HMBOX1 IKZF1 KRT31 KRT40 KRT8 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP4-2 L3MBTL3 LONRF1 LTV1 LZTS2 MID1 MID2 MIPOL1 MRFAP1L1 MTUS2 NECAB2 OLIG3 PDE4DIP PHC2 PNMA1 PNMA2 RALYL SMN2 SSX2IP STX11 TEKT1 THAP1 TNIP1 TRAF4 TRIM27 TRIM37 TRIM54 TRIP6 TRO TROAP UBE2H VPS37B ZBTB14 ZBTB8A ZFP64	44 interactors: ANAPC10 ANAPC13 APOL1 ATRIP BCAS3 BYSL CCDC24 CCDC36 CDC16 CDH1 CDT1 CEP44 COIL CRACR2A CTBP1 CYB5R2 DLX6-AS1 EIF5A2 FAM9B FBXO5 GORASP2 HEMK1 INCA1 INPP5J KCTD6 KDM1A LZTS2 MAPK3 OPTN PNMA5 RAC1 RAD54B RBM15B RBPMS RSL24D1 SIAH1 SLC52A2 SOX5 SPERT SSX2IP SUV39H1 TRIM27 TSC22D4 UBE2S
Entrez ID		705	8697
HPRD ID		04848	07221
Ensembl ID		ENSG00000112578	ENSG00000094880
Uniprot IDs		Q13895	Q9UJX2
PDB IDs
Enriched GO Terms of Interacting Partners?		Gene Expression Protein Localization To Microtubule RNA Metabolic Process Regulation Of Protein Binding Transcription, DNA-templated Negative Regulation Of Cytoskeleton Organization RNA Biosynthetic Process Cell Adhesion Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Protein Complex Disassembly Negative Regulation Of Biosynthetic Process Dendritic Cell Migration Negative Regulation Of Viral Transcription Protein Localization To Cytoskeleton Protein Modification By Small Protein Conjugation Regulation Of Viral Release From Host Cell Protein K11-linked Ubiquitination Regulation Of Protein Depolymerization Regulation Of Cellular Process Negative Regulation Of RNA Biosynthetic Process Organelle Organization Regulation Of Binding Regulation Of Metabolic Process Regulation Of Protein Complex Disassembly Cellular Macromolecule Biosynthetic Process Immune System Process Macromolecule Biosynthetic Process Negative Regulation Of Microtubule Depolymerization Cellular Component Assembly Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Neutrophil Differentiation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Memory T Cell Proliferation Regulation Of Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Developmental Process Microtubule-based Process Leukocyte Cell-cell Adhesion Negative Regulation Of Transcription From RNA Polymerase II Promoter	Protein K11-linked Ubiquitination Cell Cycle Regulation Of Organelle Organization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Protein Polyubiquitination Regulation Of Ubiquitin-protein Transferase Activity Cell Cycle Process Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Chromosome Organization Organelle Organization Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Cell Division Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Cellular Component Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Transferase Activity Protein Ubiquitination Cell Cycle Checkpoint Protein Modification By Small Protein Conjugation Activation Of Anaphase-promoting Complex Activity Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		c6ofr49 c6orf49 ccnd2 ccnd3 ccne1 cdk6 cdkn1a cdkn1b cdkn2a cdkn2b cdkn2c cdkn2d datasets disequilibrium frs3 genotyped heredity kip1 p15 p18 p19 p33 participating pgc rs2479717 tagging tags trfp usp49	34c annexin arrest atlas basal breast ccnd1 cdk4 cdk6 downregulated ectopic g2 incorporation inducing influenced mediator microrna mimicked mir mirna mirnas mitotic prkca qpcr sirnas suppressed suppressor tcga thymidine
Tagcloud (Difference) ?		c6ofr49 c6orf49 ccnd2 ccnd3 ccne1 cdkn1a cdkn1b cdkn2a cdkn2b cdkn2c cdkn2d datasets disequilibrium frs3 genotyped heredity kip1 p15 p18 p19 p33 participating pgc rs2479717 tagging tags trfp usp49	34c annexin arrest atlas basal breast ccnd1 cdk4 downregulated ectopic g2 incorporation inducing influenced mediator microrna mimicked mir mirna mirnas mitotic prkca qpcr sirnas suppressed suppressor tcga thymidine
Tagcloud (Intersection) ?		cdk6