BYSL and VPS37B

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid)

		BYSL	VPS37B
Name		bystin like	VPS37B subunit of ESCRT-I
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Membrane Preribosome, Small Subunit Precursor Apical Part Of Cell	ESCRT I Complex Cytoplasm Endosome Plasma Membrane Endosome Membrane Membrane Midbody Late Endosome Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding	Protein Binding Calcium-dependent Protein Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) In Utero Embryonic Development Blastocyst Formation Trophectodermal Cell Differentiation RRNA Processing Ribosome Biogenesis Stem Cell Proliferation Regulation Of Protein Localization To Nucleolus	Protein Targeting To Membrane Protein Targeting To Vacuole Protein Transport Macroautophagy Viral Release From Host Cell Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission Positive Regulation Of Viral Budding Via Host ESCRT Complex
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
GWAS		Hematological parameters ( 19820697 ) Mean corpuscular hemoglobin ( 19862010 20139978 ) Mean corpuscular volume ( 19862010 20139978 23263863 ) Menarche (age at onset) ( 25231870 27182965 ) Metabolite levels ( 23823483 ) Monocyte percentage of white cells ( 32888494 ) Red blood cell count ( 20139978 )	A body shape index ( 34021172 ) Hip circumference adjusted for BMI ( 34021172 ) Tourette syndrome ( 30818990 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		138 interacting genes: AIMP2 AMOTL2 APP ATP5F1B AXIN2 BEND7 BFSP1 BHLHE40 C1orf94 CAVIN4 CCDC102B CCDC136 CCDC33 CDC23 CDCA7L CEP44 CEP57L1 CEP70 COIL DDX17 DOCK8 DRC4 DVL2 EAPP EIF4ENIF1 EMD EPS8 FAM228A FAM9B FCHO1 FXR1 FXR2 GMCL1 GOLGA2 GOLGA6L9 GRIPAP1 HMBOX1 HOMEZ HOOK2 HSF2BP IKZF1 IKZF3 JRK KATNAL1 KIFC3 KLHL2 KLHL6 KRT31 KRT40 KRT8 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP4-2 L3MBTL3 LDOC1 LHX3 LMNA LMO1 LMO2 LONRF1 LZTS1 LZTS2 MB21D2 MCIDAS MEOX1 MEOX2 MID1 MID2 MIPOL1 MKRN1 MRFAP1L1 MTUS2 NECAB2 NF2 OGT OLIG3 OSBPL3 PDE4DIP PHC2 PICK1 PIH1D1 PNMA1 PNMA2 PRICKLE1 PSMC6 RACGAP1 RALY RALYL RBAK RP9 RUBCN SMN1 SMN2 SNW1 SSX2IP STX11 TBC1D26 TEKT1 TFIP11 THAP1 TLE5 TNIP1 TRAF2 TRAF4 TRAK1 TRIM14 TRIM27 TRIM37 TRIM38 TRIM41 TRIM54 TRIM55 TRIP6 TRO TROAP USH1G USO1 VIM VPS37B VPS52 WASF3 WTAP ZBTB14 ZBTB8A ZC2HC1C ZFP64 ZMAT5 ZNF212 ZNF286A ZNF426 ZNF438 ZNF48 ZNF655 ZNF668 ZNF71 ZNF835 ZSCAN22	27 interacting genes: BAG3 BYSL CDC73 CRK DCUN1D1 ENKD1 ERCC1 EXOC8 FBF1 GORASP2 HGS KDM1A LNX1 NCK2 OSTF1 PRKAA1 PRKAA2 QARS1 SH3YL1 SMARCD1 SORBS3 TLE5 TSG101 UBASH3A UBASH3B UBC VPS28
Entrez ID		705	79720
HPRD ID		04848	07794
Ensembl ID		ENSG00000112578	ENSG00000139722
Uniprot IDs		Q13895	Q9H9H4
PDB IDs		6G18 6G4S 6G4W 7WTT 7WTU 7WTV 7WTW 7WTX 7WTZ 7WU0	6VME
GO Terms Enriched among Interactors		Identical Protein Binding Protein Binding Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Microtubule Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Intermediate Filament Microtubule Binding Cytoplasm Cytoskeleton Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Keratin Filament Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytosol Fibrillar Center TORC1 Complex Assembly Cellular Response To Muramyl Dipeptide Regulation Of Gene Expression Microtubule-based Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Organelle Organization Ubiquitin Protein Ligase Activity Cajal Body Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Segment Specification Negative Regulation Of Viral Transcription Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cytoskeleton Organization Regulation Of Viral Transcription Centrosome Cycle Microtubule Organizing Center Organization Nuclear Pore Localization Transcription Coactivator Activity Somite Specification Cytoplasmic Ribonucleoprotein Granule Response To Muramyl Dipeptide Supramolecular Fiber Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Organelle Assembly Protein Localization To Vacuole Membrane Fission Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Ubiquitin-dependent Endocytosis Autophagy Endosome Organization Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Protein Localization To Lipid Droplet Multivesicular Body Assembly Multivesicular Body Organization Late Endosome To Vacuole Transport Negative Regulation Of Signal Transduction Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Localization Organelle Organization Positive Regulation Of Protein Localization Regulation Of Tubulin Deacetylation Regulation Of Protein Modification Process Lipid Droplet Disassembly Multivesicular Body Sorting Pathway Cytoplasm Protein Localization To Lysosome Phosphatidylethanolamine Biosynthetic Process Ciliary Basal Body Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Nucleotide-activated Protein Kinase Complex Establishment Of Protein Localization To Vacuole ESCRT I Complex Regulation Of Cellular Component Organization Protein-containing Complex Binding Positive Regulation Of Cellular Component Organization Positive Regulation Of Exosomal Secretion Regulation Of Signal Transduction Fatty Acid Homeostasis Hepatocyte Apoptotic Process Regulation Of Organelle Organization Cellular Response To Prostaglandin E Stimulus Regulation Of Exosomal Secretion Cellular Component Assembly Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process