FASLG and BAIAP2L1

Number of citations of the paper that reports this interaction (PMID 19807924)
2

Data Source:
BioGRID (unspecified method)

		FASLG	BAIAP2L1
Gene Name		Fas ligand (TNF superfamily, member 6)	BAI1-associated protein 2-like 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Actin Binding Proline-rich Region Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Plasma Membrane Organization Response To Bacterium Positive Regulation Of Actin Filament Polymerization Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)	Obesity-related traits ( 23251661) Prostate cancer (gene x gene interaction) ( 22219177) Sex hormone-binding globulin levels ( 22829776)
Protein-Protein Interactions		74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	6 interactors: FASLG KHDRBS1 MDM2 TP53 WAS YWHAG
Entrez ID		356	55971
HPRD ID		00610	11270
Ensembl ID		ENSG00000117560	ENSG00000006453
Uniprot IDs		P48023 Q53ZZ1	Q9UHR4
PDB IDs		1BZI	2KXC 2LNH
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway	Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Mitotic Cell Cycle Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Mitotic Cell Cycle Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Necroptotic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Signal Transduction By P53 Class Mediator Programmed Necrotic Cell Death Regulation Of Cellular Localization Cell Cycle Process Necrotic Cell Death Cell Death Death Regulation Of Catalytic Activity Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of RNA Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Cellular Response To UV Positive Regulation Of Mitochondrion Organization Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Neuron Apoptotic Process Response To Antibiotic Positive Regulation Of Organelle Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Immune Response Regulation Of Signal Transduction Signal Transduction Negative Regulation Of Cell Cycle Mitotic G1 DNA Damage Checkpoint Negative Regulation Of Gene Expression Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Negative Regulation Of Biosynthetic Process Positive Regulation Of Neuron Death Cell Cycle
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	amphiphysin bai1 bar bin cdkn2a ch5183284 constitutive debio deltabar dimerization discovered f3 fgfr fgfr3 fibroblast fusion harboring oncogenic rat rat2 rb1 rearrangements rvs screens signature suppressive transfectant transforming tumorigenic
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	amphiphysin bai1 bar bin cdkn2a ch5183284 constitutive debio deltabar dimerization discovered f3 fgfr fgfr3 fibroblast fusion harboring oncogenic rat rat2 rb1 rearrangements rvs screens signature suppressive transfectant transforming tumorigenic
Tagcloud (Intersection) ?