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FASLG and YES1
Number of citations of the paper that reports this interaction (PubMedID
19807924
)
40
Data Source:
BioGRID
(unspecified method)
FASLG
YES1
Description
Fas ligand
YES proto-oncogene 1, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Lysosome
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Perinuclear Region Of Cytoplasm
Cytoplasmic Vesicle Lumen
Extracellular Exosome
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Anchoring Junction
Molecular Function
Signaling Receptor Binding
Death Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Transmembrane Transporter Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Cell Apoptotic Process
Immune Response
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Population Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Angiogenesis
Intracellular Chloride Ion Homeostasis
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Retinal Cell Programmed Cell Death
Endosomal Lumen Acidification
T Cell Apoptotic Process
Necroptotic Process
Response To Growth Factor
Cellular Response To Type II Interferon
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum
Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of D-glucose Transmembrane Transport
Cell Differentiation
T Cell Costimulation
Cellular Response To Platelet-derived Growth Factor Stimulus
Protein Modification Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Vascular Permeability
Positive Regulation Of Transcription By RNA Polymerase II
Ephrin Receptor Signaling Pathway
Leukocyte Migration
Cellular Response To Retinoic Acid
Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
Interleukin-4 and Interleukin-13 signaling
Dimerization of procaspase-8
FasL/ CD95L signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
FOXO-mediated transcription of cell death genes
TNFs bind their physiological receptors
Signaling by ERBB2
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
FCGR activation
PECAM1 interactions
EPH-Ephrin signaling
Co-stimulation by CD28
Co-inhibition by CTLA4
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
RUNX2 regulates osteoblast differentiation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Dasatinib
Fostamatinib
Diseases
Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic sensitization (
30013184
)
Asthma (
30929738
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
24999842
25920553
20190752
)
Crohn's disease (
21102463
23128233
)
Daytime sleep phenotypes (
27126917
)
Itch intensity from mosquito bite (
28199695
)
Psoriasis (
28537254
)
Systemic lupus erythematosus (
28714469
)
Type 1 diabetes (
34127860
)
Vitiligo (
27723757
)
Diastolic blood pressure (
29403010
30487518
)
Hypertension (
30487518
)
Mean arterial pressure (
29403010
30487518
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Pulmonary function in asthmatics (
23541324
)
Pursuit maintenance gain (
29064472
)
Systolic blood pressure (
29403010
30224653
30487518
30578418
)
Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) (
31794020
)
Interacting Genes
82 interacting genes:
APBB1
ARHGAP9
BAIAP2L1
BTK
CACNB3
CACNB4
CRK
CYSRT1
DAXX
DLG2
DMD
DNMBP
DOCK4
ECM1
EPS8L3
EZR
FADD
FAS
FGR
FN1
FNBP1
FYB1
FYN
GRAP
GRAP2
GRB2
HCK
IHO1
ITK
ITSN2
KALRN
KMT2A
KRT33B
KRT40
KRTAP11-1
KRTAP12-3
LCK
LYN
MACC1
MIA
MMP7
MPP4
MYO15A
NCF1
NCK1
NCK2
NCKIPSD
NOTCH2NLA
OSTF1
PACSIN2
PDCD6
PIK3CA
PIK3R1
PIN1
PPIAP11
PRPF40A
PSTPIP1
PTPN13
RGS20
RIMBP3C
SAMSN1
SEC23A
SH3GL3
SH3PXD2A
SH3PXD2B
SH3RF2
SKAP2
SNX33
SNX9
SORBS3
SPTA1
SRC
SRGAP1
SRGAP2
SRGAP3
SUMO1
TEC
TJP3
TNFRSF6B
TNS2
TRIP6
YES1
98 interacting genes:
ADAM12
ADAM15
AMOTL2
AR
BCAR1
BECN1
BICD2
C1orf94
CARD9
CBL
CBLB
CBLC
CCDC33
CD2AP
CD36
CD46
CDH1
CDKN1B
CEP57L1
CEP83
CHMP1A
CPSF6
CRKL
CSF1R
DDIT4L
DENND2C
DES
DLG4
DOK1
DOK2
DRC4
DTX3
DVL2
EFS
EGFR
EPHB2
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FLACC1
FLT1
FUNDC1
FXR1
FXR2
GAB1
GFAP
GP6
IKZF3
ITGB4
JAK2
JAKMIP1
KDR
KHDRBS1
KIT
LASP1
LIN7C
MET
MST1R
NEDD4
NHERF1
NIF3L1
NPHS1
OGT
PAK2
PDCD6IP
PDGFRB
PECAM1
PICK1
PIK3R3
PTEN
PTK2
PTPRE
RASA1
RPL10
SH3GLB2
SKAP2
SOCS1
SOCS2
SOCS3
SOCS7
SPRR2A
SSBP3
STAP2
THAP1
TNK2
TP53BP2
TRAF2
TRAF6
TRIM5
TRPV4
TSGA10IP
TYRO3
ZBTB8A
ZC2HC1A
ZNF438
ZNF512B
Entrez ID
356
7525
HPRD ID
00610
01285
Ensembl ID
ENSG00000117560
ENSG00000176105
Uniprot IDs
P48023
Q53ZZ1
P07947
PDB IDs
4MSV
5L19
5L36
2HDA
Enriched GO Terms of Interacting Partners
?
Phosphotyrosine Residue Binding
Non-membrane Spanning Protein Tyrosine Kinase Activity
Cytosol
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Signal Transduction
Antigen Receptor-mediated Signaling Pathway
Immune Response-activating Signaling Pathway
Regulation Of Immune Response
Immune Response-regulating Signaling Pathway
T Cell Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Activation Of Immune Response
Regulation Of Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Plasma Membrane
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Regulation Of Cellular Component Organization
Cytoplasm
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Ephrin Receptor Binding
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Immune System Process
Positive Regulation Of Immune Response
Regulation Of Cell Shape
Regulation Of Cell Morphogenesis
Negative Regulation Of Immune System Process
Regulation Of Actin Filament-based Process
Positive Regulation Of Immune System Process
T Cell Costimulation
Regulation Of Cell Communication
Regulation Of Signaling
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Actin Filament Polymerization
Regulation Of Signal Transduction
Developmental Process
Phospholipase Activator Activity
Endocytosis
B Cell Receptor Signaling Pathway
Regulation Of Cell Motility
Immune System Process
Regulation Of Cell Activation
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Actin Polymerization Or Depolymerization
Anchoring Junction
Positive Regulation Of T Cell Activation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Receptor Complex
Positive Regulation Of Signal Transduction
Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Signaling
Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Protein Phosphorylation
Regulation Of Intracellular Signal Transduction
Identical Protein Binding
Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Migration
Regulation Of Apoptotic Process
Plasma Membrane
Regulation Of Protein Modification Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Motility
Regulation Of Developmental Process
Cell Migration
Negative Regulation Of Programmed Cell Death
Regulation Of Cellular Component Organization
Regulation Of Locomotion
Positive Regulation Of Phosphate Metabolic Process
Response To Growth Factor
Positive Regulation Of Protein Modification Process
Protein Kinase Activity
Cell Motility
SH3 Domain Binding
Regulation Of Protein Metabolic Process
Regulation Of Protein Kinase Activity
Protein Binding
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Population Proliferation
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Tagcloud (Intersection)
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